Detralex, 500 mg 30 pcs.

Pharmgroup:

Venotonizing and venoprotective agent.

Pharmacological action:

DETRALEX has venotonic and angioprotective properties.

The drug reduces venous distensibility and venous stasis, decreases capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug with respect to indicators of venous hemodynamics.

A statistically significant dose-dependent effect of DETRALEX was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time. The optimal dose-effect ratio is observed when taking 2 tablets.

DETRALEX increases venous tone: venous occlusion plethysmography showed a decrease in venous emptying time. In patients with signs of severe microcirculatory disorders a statistically significant increase of capillary resistance evaluated by angiostereometry after DETRALEX therapy was observed compared to placebo.

Therapeutic effectiveness of DETRALEX has been proven in treatment of chronic diseases of lower limb veins and in treatment of hemorrhoids.

Pharmacokinetics:

The main excretion of the drug is in the feces. With the urine on average about 14% of the taken amount of the drug is excreted.

The elimination half-life is 11 hours.

The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in the urine.

Indications

Varicose veins, Pain, Heaviness and pain in the legs, Hemorrhoids, Anal fissures, Trophic ulcers, Cramps of the calf muscles

Symptomatic therapy of venous and lymphatic insufficiency, feeling of heaviness in the legs, pain, “Morning fatigue” of the legs, cramps, trophic disorders, symptomatic therapy of exacerbation of hemorrhoids.

Active ingredient

Purified micronized flavonoid fraction (diosmin, flavonoids in terms of hesperidin)

Composition

1 tablet contains:

Active ingredients:

purified micronized flavonoid fraction 500 mg ( including diosmin (90%) 450 mg,

Flavonoids expressed as hesperidin (10%) 50 mg);

Associates:

gelatin,

magnesium stearate,

microcrystalline cellulose,

sodium starch glycolate,

talc,

glycerol,

macrogol 6000,

Hydroxypropyl methylcellulose,

Iron oxide yellow (E172),

Red iron oxide (E172),

Titanium dioxide (E171),

Sodium lauryl sulfate.