Detragel, gel 40 g

Combination drug, has local anticoagulant, anti-inflammatory, venotonic and anti-aggregant effect, reduces venous permeability, improves microcirculation.

Detragel® contains three active ingredients: sodium heparin, essential phospholipids and escin, which have pharmacodynamic and pharmacokinetic synergism.

Sodium heparin is a direct acting anticoagulant. Due to inactivation of biogenic amines and blocking of lysosomal enzymes in the tissue it shows anti-inflammatory effect, accelerates dissolution of micro clots in the subcutaneous capillaries, prevents thrombosis, activates the fibrinolytic system, improves microcirculation, promotes regeneration of connective tissue due to inhibition of hyaluronidase activity.

Essential phospholipids decrease blood viscosity through their influence on fat metabolism and decrease the process of platelet aggregation.

Escin is a venotonic agent of plant origin. It prevents the activation of lysosomal enzymes that break down proteoglycan, increases the tone of the venous wall, eliminates venous stasis, decreases capillary permeability and fragility. It reduces exudation, decreases effusion of fluid into tissues and accelerates resorption of existing edema. Inhibits inflammatory processes, improves microcirculation, promotes tissue repair.

Indications

Detragel® is indicated for use in adults for the following indications:
Treatment of symptoms of chronic venous diseases.
Varicose veins with symptoms in the form of pain, swelling, a feeling of heaviness and fatigue in the legs, night cramps of the calf muscles, and with signs in the form of telangiectasia (spider veins and spider veins) and varicose veins.
Superficial phlebitis, thrombophlebitis.
Hematomas from injuries, including sports sprains and bruises.
Postoperative hematomas without violating the integrity of the skin.
If your condition worsens or improvement does not occur after 15 days of using the drug, you should contact your doctor.

Pharmacological effect

Detragel® belongs to a group of drugs called angioprotectors, drugs for the treatment of varicose veins, heparins or topical heparinoids.

Mode of action of the drug Detragel®

The combination of active ingredients in the drug Detragel® after the first use helps to reduce the symptoms of varicose veins.
Helps reduce pain, accelerate the resorption of swelling, reduce the feeling of heaviness and fatigue in the legs. The drug Detragel® has an anti-inflammatory effect and promotes tissue healing, prevents the formation of blood clots, increases the tone of the venous wall, and eliminates venous congestion.

Due to its anticoagulant properties, sodium heparin enhances capillary blood circulation, thus preventing the formation of microthrombi. It also has an anti-inflammatory effect, as it facilitates the absorption of inflammatory products.

Escin increases blood flow through the veins and capillaries, improves tone and normalizes the permeability of vascular walls.

Essential phospholipids reduce blood viscosity due to their effect on fat metabolism and thus stimulate blood circulation through arterioles and capillaries. They also have a protective effect on the skin.

Special instructions

Driving vehicles and working with machinery

No studies have been conducted to study the effect of Detragel® on the ability to drive vehicles and operate machinery.

The drug Detragel® contains methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate.

These excipients may cause allergic reactions (including delayed ones).

Active ingredient

Heparin sodium, Phospholipids, Escin

Composition

The active ingredients are sodium heparin, essential phospholipids and escin.

1 g of gel contains: 100 IU sodium heparin, 10 mg essential phospholipids, 10 mg escin.

Other ingredients (excipients) are: isopropanol, glycerol 85%, trolamine, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer-980, cologne, rosemary oil, lavender oil, water.

Pregnancy

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to become pregnant, before starting to use this medicine
consult your doctor or pharmacist.

Contraindications

Do not use Detragel®:
if you are allergic to sodium heparin, essential phospholipids, escin or any of the excipients (listed in section 6 of the leaflet);
if you have hemorrhagic diathesis (including thrombocytopenic purpura,
hemophilia);
if you have a violation of the integrity of the skin at the site of application of the drug (open wounds, ulcerative necrotic lesions);
if you have burns, eczema, skin infections at the site of application of the drug;
If you think any of the following applies to you, tell your healthcare provider.

Application of the gel to mucous membranes is contraindicated.

Special instructions and precautions

Before using Detragel®, consult your doctor:
if you have deep vein thrombosis (a condition characterized by the formation of blood clots in the deep veins),
if you have a tendency to bleed or bleed,
if you are taking medications to reduce blood clotting (indirect anticoagulants, for example, warfarin, acenocoumarol),
You may need to contact your healthcare provider to determine your prothrombin time and blood clotting time.
In case of allergic reactions (redness of the skin, skin rash, itching), including delayed ones (contact dermatitis), the use of the drug should be stopped immediately and seek medical help.
If your condition worsens (increased pain, swelling, redness of the skin, signs of inflammation), you should immediately contact your doctor, since the symptoms described may be a sign of a more serious illness.
Children and teenagers

Do not use the drug in children aged 0 to 18 years due to the fact that there is no data on the effectiveness and safety of Detragel®.

Side Effects

Like all medicines, Detragel® can cause side effects, although not everyone gets them.

The following adverse reactions are very rare (may affect up to 1 in 10,000 people):

– difficulty breathing caused by contraction of the muscles of the bronchi (bronchospasm),
– inflammation of the skin caused by contact with an irritating substance (contact dermatitis – a delayed-type allergic reaction),
– skin rash, itching, urticaria (immediate allergic reactions).

In these cases, use of the drug should be stopped immediately and medical help should be sought.

Interaction

Tell your doctor or pharmacist if you are using, have recently used, or may start using any other medications.

Do not apply Detragel® to the same area of ​​skin at the same time as other medications for external use.

Overdose

If you think that you have used more Detragel® than you should, contact your doctor.

Storage conditions

At a temperature not exceeding 25 °C.

Manufacturer

Bosnalek JSC, Bosnia and Herzegovina