De-Nol, 120 mg 56 pcs.

Pharmacokinetics
Bismuth subcitrate is practically not absorbed from the gastrointestinal tract. It is excreted mainly with the feces. A small amount of bismuth in the plasma is excreted by the kidneys. De-Nol is gastroprotective, antiulcer, antibacterial. Pharmacodynamics An antiulcer agent with bactericidal activity against Helicobacter pylori.

Indications

peptic ulcer of the stomach and duodenum in the acute phase, incl. associated with Helicobacter pylori;
chronic gastritis and gastroduodenitis in the acute phase, incl. associated with Helicobacter pylori;
irritable bowel syndrome, which occurs predominantly with symptoms of diarrhea;
functional dyspepsia not associated with organic gastrointestinal diseases.

Pharmacological effect

Pharmacokinetics
Bismuth subcitrate is practically not absorbed from the gastrointestinal tract. It is excreted mainly in feces. A small amount of bismuth entering the plasma is excreted from the body by the kidneys. De-Nol – gastroprotective, antiulcer, antibacterial. Pharmacodynamics Antiulcer agent with bactericidal activity against Helicobacter pylori.

Special instructions

The drug should not be used for more than 8 weeks. It is also not recommended to exceed the established daily doses for adults and children during treatment. During treatment with De-Nol®, you should not use other drugs containing bismuth. At the end of a course of treatment with the drug in recommended doses, the concentration of the active substance in the blood plasma does not exceed 3–58 mcg/l, and intoxication is observed only at concentrations above 100 mcg/l.

When using De-Nol®, stool may turn dark due to the formation of bismuth sulfide. Sometimes there is a slight darkening of the tongue.

Active ingredient

Bismuth tripotassium dicitrate

Composition

Active ingredient:

bismuth tripotassium dicitrate 304.6 mg;

Excipients:

corn starch – 70.6 mg,

povidone K30 – 17.7 mg,

potassium polyacrylate – 23.6 mg,

macrogol 6000 – 6 mg,

magnesium stearate – 2 mg

Contraindications

pregnancy; breastfeeding period.

Side Effects

From the digestive system: nausea, vomiting, more frequent bowel movements, and constipation may occur. These phenomena are not dangerous to health and are temporary.

Allergic reactions: skin rash, skin itching.

Interaction

For half an hour before and after taking De-Nol®, it is not recommended to take other drugs internally, as well as take food and liquids, in particular antacids, milk, fruits and fruit juices.

This is due to the fact that when taken orally simultaneously, they can affect the effectiveness of De-Nol®.

Overdose

Symptoms from the drug (with long-term use of doses exceeding the recommended): impaired renal function. These symptoms are completely reversible when De-Nol® is discontinued.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

ZiO-Zdorovye CJSC, Russia