Daivonex, ointment 50 mcg/g 30 g

Pharmacodynamics

The drug for the treatment of psoriasis.

Calcipotriol is a synthetic analog of the active metabolite of vitamin D , stimulates morphological differentiation and inhibits proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.

Calcipotriol is a potent inhibitor of interleukin I-induced T-lymphocyte activation.

The effect of calcipotriol on calcium metabolism is 100 times weaker than vitamin D₃.

Pharmacokinetics

The transdermal absorption of calcipotriol is, depending on the dose used, 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver to form pharmacologically inactive metabolites. T _1/2 is very short.

Indications

Psoriasis, Skin itching

Psoriasis vulgaris, including chronic psoriasis of the scalp.

Active ingredient

Calcipotriol

Composition

Active ingredient:

Calcipotriol 50 µg.

Associates:

dinatrium edetate,

sodium hydrophosphate,

α-tocopherol,

liquid paraffin,

polyethylene glycol stearate,

propylene glycol,

white paraffin,

water.

How to take, the dosage

The ointment is applied in a thin layer to the affected areas of the skin 2 times a day. Therapeutic effect is usually observed after 1-2 weeks of treatment. The duration of the course of treatment is not more than 6-8 weeks.

• Adults: maximum daily dose is 15 g, maximum weekly dose – not more than 100 grams.
• For children over 12 years of age: the maximum dose per week is 75 g.
• For children aged 6 to 12 years: the maximum dose per week is no more than 50 g.

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Interaction

Diveonex should not be used at the same time as topical medications containing salicylic acid.

Special Instructions

It is not recommended to apply the ointment to the skin of the face.

To avoid contact of the drug with the skin of the face, hands should be thoroughly washed after each application of the ointment.

Hypercalcemia develops when the maximum dose of calcipotriol is exceeded in a week. When the drug is discontinued, the calcium concentration in the blood quickly normalizes.

The treatment with Daivonex can be combined with PUVA therapy.

Impact on ability to drive vehicles and other mechanisms requiring increased concentration

Dyvonex does not affect the ability to drive vehicles and operate machinery.

Contraindications

• High sensitivity to the drug components.
• Diseases accompanied by impaired calcium metabolism.

With caution, use the drug in: hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis. In children in case of lack of experience. In patients over 65 years of age.

Side effects

Dermatological reactions: local skin irritation, erythema and skin itching are possible; dermatitis, exacerbation of psoriasis is rare; in some cases – hyperpigmentation, photosensitization.

Metabolism: hypercalciuria, hypercalcemia.

Overdose

Symptoms: if the drug is used in doses higher than recommended, the blood calcium concentration may increase.

Treatment: discontinue the drug.

Pregnancy use

The safety of the drug during pregnancy and lactation has not been established.

It is unknown whether calcipotriol is excreted with breast milk.