Daivonex, ointment 50 mcg/g 30 g

Pharmacodynamics

The drug for the treatment of psoriasis.

Calcipotriol is a synthetic analog of the active metabolite of vitamin D , stimulates morphological differentiation and inhibits proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.

Calcipotriol is a potent inhibitor of interleukin I-induced T-lymphocyte activation.

The effect of calcipotriol on calcium metabolism is 100 times weaker than vitamin D₃.

Pharmacokinetics

The transdermal absorption of calcipotriol is, depending on the dose used, 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver to form pharmacologically inactive metabolites. T _1/2 is very short.

Indications

Vulgar psoriasis, incl. chronic psoriasis of the scalp.

Pharmacological effect

Pharmacodynamics

A drug for the treatment of psoriasis.

Calcipotriol is a synthetic analogue of the active metabolite of vitamin D, stimulates morphological differentiation and suppresses the proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.

Calcipotriol is a potent inhibitor of interleukin I-induced T cell activation.

The effect of calcipotriol on calcium metabolism is 100 times weaker than that of vitamin D3.

Pharmacokinetics

Transdermal absorption of calcipotriol ranges from 1% to 5%, depending on the dose used. Calcipotriol undergoes rapid biotransformation in the liver with the formation of pharmacologically inactive metabolites. T 1/2 is very short.

Special instructions

It is not recommended to apply the ointment to the skin of the face.

To avoid contact of the drug with the skin of the face, hands should be washed thoroughly after each use of the ointment.

Hypercalcemia develops when the maximum dose of calcipotriol per week is exceeded. When the drug is discontinued, the concentration of calcium in the blood quickly normalizes.

Treatment with Daivonex can be combined with PUVA therapy.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration

Daivonex does not affect the ability to drive vehicles or operate machinery.

Active ingredient

Calcipotriol

Composition

Active ingredient:

calcipotriol 50 mcg.

Excipients:

disodium edetate,

sodium hydrogen phosphate,

α-tocopherol,

liquid paraffin,

polyethylene glycol stearate,

propylene glycol,

white paraffin,

water.

Pregnancy

The safety of the drug during pregnancy and lactation has not been established.

It is not known whether calcipotriol is excreted in breast milk.

Contraindications

Hypersensitivity to the components of the drug.
Diseases accompanied by impaired calcium metabolism.

The drug should be used with caution in case of: hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis. In children due to lack of experience in use. In patients over 65 years of age.

Side Effects

Dermatological reactions: possible – local skin irritation, erythema and itching of the skin; rarely – dermatitis, exacerbation of psoriasis; in some cases – hyperpigmentation, photosensitivity.

Metabolism: hypercalciuria, hypercalcemia.

Interaction

Daivonex should not be used concomitantly with topical preparations containing salicylic acid.

Overdose

Symptoms: when using the drug in doses higher than recommended, it is possible to increase the concentration of calcium in the blood.

Treatment: drug withdrawal.

Storage conditions

Store at a temperature not exceeding 25°C.
Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

LEO Laboratories Limited, Ireland