D-Panthenol-Nizhpharm, cream 5% 25 g

Dexpanthenol is a derivative of pantothenic acid. < br> < br> < br> Dexpanthenol is converted in the body into pantothenic acid, which is part of coenzyme A and is involved in the processes of acetylation, in the synthesis of acetylcholine, corticosteroids, porphyrins. < In addition, it is involved in virtually all metabolic processes (tricarboxylic acid cycle, metabolism of carbohydrates, fats and fatty acids, phospholipids, proteins, etc.), stimulates skin and mucous membrane regeneration, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. < br> < br> It has regenerating, metabolic and weak anti-inflammatory effect. < br> < br> When applied externally it is quickly absorbed by skin and converted to pantothenic acid, binds to plasma proteins (mainly beta-globulin and albumin). < br> < br> Its concentration in blood is 0.5-1 mg/l, in blood serum – 100 µg/l. Pantothenic acid is not metabolized in the body (except for inclusion in Co-A) and is excreted unchanged.< br> < br> < br>

Indications

In case of violation of the integrity of the skin: healing of burns (including sunburn), minor skin damage (abrasions, cuts, cracks, etc.).
Prevention and treatment of dry skin, including as a consequence of dermatitis of various origins (manifested by peeling, redness, irritation, feeling of tightness), as well as daily care of areas of the skin exposed to the greatest influence of external factors (face, hands), including due to chapping.
For caring for the mammary gland during lactation (cracks and redness of the nipples of the mammary gland), for caring for infants and infants (diaper rash, diaper dermatitis).

Pharmacological effect

Dexpanthenol is a derivative of pantothenic acid.

Dexpanthenol is converted into pantothenic acid in the body, which is a component of coenzyme A and is involved in acetylation processes, in the synthesis of acetylcholine, corticosteroids, and porphyrins.

In addition, it takes part in almost all metabolic processes (tricarboxylic acid cycle, metabolism of carbohydrates, fats and fatty acids, phospholipids, proteins, etc.), stimulates the regeneration of skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers.

It has a regenerating, metabolic and mild anti-inflammatory effect.

When applied externally, it is quickly absorbed by the skin and converted into pantothenic acid, binds to plasma proteins (mainly beta-globulin and albumin).

Its concentration in the blood is 0.5-1 mg/l, in the blood serum – 100 μg/l. Pantothenic acid is not metabolized in the body (except for inclusion in Co-A) and is excreted unchanged.

Special instructions

For external use only.
Do not apply to wet wounds.

Effect on the ability to drive vehicles and machinery The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Dexpanthenol

Composition

1 g of cream contains:

active ingredient:

dexpanthenol 50 mg;

excipients:

propylene glycol 100 mg,

methyl parahydroxybenzoate 0.8 mg,

propyl parahydroxybenzoate 0.2 mg,

macrogol cetostearate 16 mg,

cetostearyl alcohol [cetyl alcohol not more than 60%, stearyl alcohol not less than 40%] 40 mg,

liquid paraffin 80 mg,

Vaseline 100 mg,

sodium hydrogen phosphate dodecahydrate 0.2 mg,

potassium dihydrogen phosphate 7.8 mg,

purified water up to 1 g.

Contraindications

Hypersensitivity to the components of the drug.

Side Effects

Allergic reactions.

Allergic skin reactions (eg, contact dermatitis, allergic dermatitis, itching, redness, eczema, rash, urticaria, skin irritation).

If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Interaction

Cases of interaction with other drugs are unknown.

Overdose

Cases of overdose are unknown.

Storage conditions

At a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

Nizhpharm JSC, Russia