In external application of minoxidil its stimulating effect on hair growth in persons with androgenic alopecia (hair thinning, baldness) has been noted.
It improves microcirculation, stimulates hair cells’ transition to the active growing phase, changes the effect of androgens on the hair follicles.
Decreases the formation of 5-alpha-dehydrotestosterone (probably indirectly), which plays a significant role in the formation of baldness. It has the best effect if the time of the disease is short (not more than 10 years), the patient is young, the baldness in the vertex is not more than 10 cm, the presence of more than 100 down and terminal hairs in the center of the baldness.
The appearance of signs of hair growth is observed after 4 or more months of using the drug. The onset and severity of the effect may vary from patient to patient.
After discontinuation of Colilon® the growth of new hair is suspended, within 3-4 months it is possible to restore the original appearance.
The exact mechanism of action of Cosilon® in treatment of androgenetic alopecia is unknown. Minoxidil is ineffective in cases of alopecia caused by taking medication, improper nutrition (iron (Fe) deficiency, vitamin A deficiency), as a result of hair styling in “tight” hairstyles.
Androgenic alopecia in men and women (in order to restore hair or stabilize hair loss).
1 ml contains minoxidil 20 mg.
How to take, the dosage
Apply 1 ml of Cosilon solution to dry scalp twice a day and gently rub in, starting from the center of the affected area.
There is a theoretical possibility of increased orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, but this possibility has not been clinically confirmed.
The very slight elevated blood levels of minoxidil in patients with arterial hypertension receiving oral minoxidil cannot be excluded when Cosilon® is used concomitantly, although appropriate clinical studies have not been performed.
Minoxidil has been found to interact with some other topical medications when used externally.
The simultaneous use of minoxidil solution for external use and cream containing betamethasone (0.05%) leads to decreased systemic absorption of minoxidil. Simultaneous application to the skin of minoxidil and topical preparations such as tretinoin and ditranol, which cause changes in skin protective functions, may result in increased absorption of minoxidil.
Cosilon® is applied only to dry scalp after bathing or at least 4 hours before bathing. Hands should be washed thoroughly after application to the scalp.
Wash hair as usual when using Cosilon®. Hairspray and other hair care products can be used while using Cosilon®. Before applying hair care products, first apply Cosilon® and wait until the area to be treated is completely dry. There is no evidence that hair coloring, perming or the use of hair softeners will impair the effectiveness of the product in any way.
However, to prevent possible scalp irritation, it is important to ensure that the drug has been completely washed from the hair and scalp before applying these chemical agents.
Prior to treatment with Cosilon®, patients should undergo a general examination that includes collection and review of medical history. The physician must ensure that the scalp is healthy.
In case of systemic side effects or severe skin reactions, patients should discontinue the drug and consult a physician.
Cosilon® contains ethyl alcohol. In case of contact of the drug with sensitive surfaces (eyes, irritated skin, mucous membranes) it is necessary to wash the area with plenty of cold water.
The effect of the drug on the ability to drive vehicles and work on machines:
Influence of the drug on psychomotor functions has not been noted. The drug does not affect the ability to operate vehicles.
Hypersensitivity to minoxidil or other components of Cosilon.
Age less than 18 years. Older age over 65 years of age.
Dermal integrity disorders, dermatoses of the scalp.
Skin disorders: hypertrichosis, thinning and increased pigmentation of body hair; with local use – dry and flaky scalp, dermatitis (itching, rash), eczema, increased alopecia, scalp burning sensation, folliculitis (sensitivity or painfulness at hair roots), erythema
Allergic reactions: rash, facial swelling, rhinitis, urticaria.
Others: sodium and water retention in the body, edema, shortness of breath, syncope, decreased libido.
Accidental oral administration of Cosilon® may cause systemic side effects due to the vasodilator properties of minoxidil (5 ml of Cosilon® contains 250 mg of minoxidil, 2.5 times the maximum recommended dose for adults when taken orally for the treatment of arterial hypertension).
The signs of overdose are fluid retention, decreased blood pressure, and tachycardia.
Treatment: to eliminate fluid retention diuretics may be prescribed if necessary; beta-adrenoblockers may be used to treat tachycardia.
In order to treat arterial hypotension 0.9% sodium chloride solution should be administered intravenously. Symptomatic agents such as norepinephrine and epinephrine with excessive cardiac stimulatory activity should not be administered.
Regain, Alerana, Alerana spray, Generolon, Alerana spray
|Conditions of storage|
At a temperature not exceeding 25 °C (do not freeze)
Bosnalek AS, Bosnia and Herzegovina
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