Corvalol, drops, 25 ml

Corvalol has sedative, antispasmodic, vasodilator effect.

Pharmacodynamics

Phenobarbital has sedative and mild sleeping pills.

Phenobarbital helps reduce CNS agitation and facilitates the onset of natural sleep. Ethylbromisovalerianate has sedative and antispasmodic effects.

Pearmint oil has reflex vasodilator and antispasmodic activity.

Indications

As a sedative and vasodilator:

As an antispasmodic agent: intestinal spasms.

Active ingredient

Composition

1000 ml of the solution contains:

acting substances:

ethyl bromisovalerianate – 20 g (ethyl ester of alpha-bromisovaleric acid),

p> phenobarbital -18.26 g,

Pearmint leaf oil – 1.42 g,

excipients:

Sodium hydroxide – 3.15 g,

Ethanol – 580 ml,

Water – 420 ml.

How to take, the dosage

Internal. The dosage is set individually. Adults are usually prescribed 15-30 drops 3 times a day before meals. In case of tachycardia single dose may be increased up to 40-50 drops. Children are prescribed 3-15 drops per day depending on the age and clinical picture of the disease.

The duration of application of the drug is determined by the physician individually.

Interaction

Drugs depressing CNS increase the effect of the drug.

Phenobarbital (microsomal oxidation inducer) may decrease the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); it increases the effect of local anesthetic, analgesic and hypnotic drugs. The drug increases the toxicity of methotrexate.

The action of the drug increases with the use of valproic acid.

Special Instructions

The drug contains 79 vol.% ethanol and phenobarbital, therefore patients taking Corvalol are not recommended to engage in activities involving increased attention and requiring rapid mental and motor reactions.

Long-term use of the drug may lead to addiction; bromine may accumulate in the body and become toxic.

If any side effects (unusual) occur, it is necessary to tell the attending physician.

Alcohol should not be consumed during the use of the drug.

It is recommended to refrain from potentially hazardous activities requiring increased concentration and quick psychomotor reactions (including driving and operating complex machinery).

Contraindications

Hypersensitivity to the components of the drug Corvalol; severe renal and/or hepatic impairment.

Side effects

Corvalol is generally well tolerated. In some cases, drowsiness and light dizziness may be observed during daytime hours.

In prolonged use in high doses, chronic bromine poisoning may develop, the manifestations of which are: depressed mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, coordination disorders.

Overdose

Symptoms: CNS depression, nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, movement coordination disorders).

The treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression – caffeine, nikethamide.