Corvalol, drops, 15 ml

A combination drug, the action of which is caused by the properties of its constituent substances.

It has sedative and antispasmodic effect. It facilitates the onset of natural sleep.

• Ethyl ester of α-bromisovaleric acid has sedative (similar to the effect of valerian) and antispasmodic action.
• Phenobarbital enhances the sedative effect of the other components, reduces CNS agitation and facilitates sleep.
• Pearmint oil has reflex vasodilatory and antispasmodic effect.
  

Indications

As a sedative and vasodilator for the following diseases:

functional disorders of the cardiovascular system (cardialgia, sinus tachycardia, increased blood pressure);
insomnia (difficulty falling asleep);
neurotic conditions;
vegetative lability;
irritability;
hypochondriacal syndrome.

As an antispasmodic:

spasm of the muscles of the gastrointestinal tract (intestinal and biliary colic).

Pharmacological effect

A combined drug whose effect is determined by the properties of its constituent substances.

Has a sedative and antispasmodic effect. Facilitates the onset of natural sleep.

Ethyl ester of α-bromoisovaleric acid has a sedative (similar to the effect of valerian) and antispasmodic effect.
Phenobarbital enhances the sedative effect of other components, helps reduce central nervous system excitation and facilitates the onset of sleep.
Peppermint oil has a reflex vasodilating and antispasmodic effect.

Special instructions

The drug contains 79 volume percent ethanol and phenobarbital, therefore patients taking Corvalol are not recommended to engage in activities associated with increased attention and requiring rapid mental and motor reactions.

With prolonged use of the drug, the formation of drug dependence is possible; it is possible to accumulate bromine in the body and develop poisoning with it.

If any side (unusual) effects occur, you should report them to your doctor.

You should not drink alcohol while using the drug.

It is recommended to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles and working with complex mechanisms).

Active ingredient

Peppermint Leaf Oil, Phenobarbital, Ethyl Bromoisovalerianate

Composition

1 ml of the drug contains:

α-bromoisovaleric acid ethyl ester 20 mg
phenobarbital 18.26 mg
peppermint leaf oil 1.42 mg

Contraindications

hypersensitivity to the components of the drug Corvalol;
severe renal and/or liver dysfunction.

Side Effects

drowsiness,
dizziness.

With long-term use of large doses, the development of chronic bromine poisoning is possible, the manifestations of which include: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, and loss of coordination.

Interaction

Medicines that depress the central nervous system enhance the effect of the drug.

Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the effect of local anesthetics, analgesics and hypnotics. The drug increases the toxicity of methotrexate.

The effect of the drug is enhanced by the use of valproic acid drugs.

Weakens the effect of glucocorticosteroids and hormonal contraceptives.

Overdose

Symptoms: central nervous system depression, nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).

Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy; in case of central nervous system depression – caffeine, niketamide.

Storage conditions

In a place protected from light, at a temperature of 10–25 °C.

Shelf life

2 years and 6 months

Manufacturer

Moscow pharmaceutical factory, Russia