Corvalol, drops, 15 ml

A combination drug, the action of which is caused by the properties of its constituent substances.

It has sedative and antispasmodic effect. It facilitates the onset of natural sleep.

• Ethyl ester of α-bromisovaleric acid has sedative (similar to the effect of valerian) and antispasmodic action.
• Phenobarbital enhances the sedative effect of the other components, reduces CNS agitation and facilitates sleep.
• Pearmint oil has reflex vasodilatory and antispasmodic effect.
  

Indications

As a sedative and vasodilator for the following conditions:

As an antispasmodic agent:

Active ingredient

Composition

1 ml of the drug contains:

How to take, the dosage

Inwards, before a meal, 15-30 drops dissolved in a small amount (30-50 ml) of water, 2-3 times a day. Single dose may be increased up to 40-50 drops if necessary (e.g. in case of tachycardia).

In children – 3-15 drops/day. (depending on the age and clinical picture of the disease).

The duration of application of the drug is determined by the doctor individually.

Interaction

Drugs depressing CNS increase the effect of the drug.

Phenobarbital (microsomal oxidation inducer) may decrease the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); it increases the effect of local anesthetic, analgesic and hypnotic agents. The drug increases the toxicity of methotrexate.

The action of the drug increases with the use of valproic acid.

Limits the effect of glucocorticosteroids and hormonal contraceptives.

Special Instructions

The drug contains 79 vol.% ethanol and phenobarbital, therefore patients taking Corvalol are not recommended to engage in activities involving increased attention and requiring rapid mental and motor reactions.

Long-term use of the drug may lead to addiction; bromine may accumulate in the body and become toxic.

If any side effects (unusual) occur, it is necessary to tell the attending physician.

Alcohol should not be consumed during the use of the drug.

It is recommended to refrain from potentially hazardous activities requiring increased concentration and quick psychomotor reactions (including driving and operating complex machinery).

Contraindications

Side effects

In prolonged use in high doses, chronic bromine poisoning may develop, the manifestations of which are: depressed mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination.

Overdose

Symptoms: CNS depression, nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, movement coordination disorders).

The treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression – caffeine, nikethamide.