Contraktubex, gel 20 g

Pharmacotherapeutic group: D03AX. Hyperrubbing treatment.

Pharmacological properties

Pharmacodynamics:
A combined drug whose action is due to the properties of its constituent components. It has a fibrinolytic anti-inflammatory effect (due to the presence of Sera extract), antithrombic (due to the presence of heparin) and keratolytic (due to the presence of allantoin). Stimulates cellular regeneration without hyperplasia. Inhibits the proliferation of kelloid fibroblasts.

Pharmacokinetics:
In the experiment it was shown that heparin for 4 hours in clinically sufficient amounts penetrates into the connective tissue of the dermis. Deep penetration is provided by the combination of heparin with extract of Serae bulbs and allantoin (transepidermal heparinization).
When using the drug Contraktubex systemic absorption is not observed.

Indications

– Hypertrophic and keloid scars that occur after surgery, amputations, burns and injuries
– Ankylosis (contractures) of joints
– Dupuytren’s contracture
– Traumatic tendon contractures
– Stretch marks after pregnancy
– Atrophic scars (in particular, those occurring after aspe or furunculosis)
– Prevention of the formation of pathological scars in the postoperative period or after an accident

Can be used in children.

Pharmacological effect

Pharmacotherapeutic group: D03AX. Hyperscarring treatment.

Pharmacological properties

Pharmacodynamics:
A combined drug whose effect is determined by the properties of its constituent components. It has fibrinolytic anti-inflammatory (due to the presence of Serae extract), antithrombic (due to the presence of heparin) and keratolytic (due to the presence of allantoin) effect. Stimulates cellular regeneration without hyperplasia. Inhibits the proliferation of keloid fibroblasts.

Pharmacokinetics:
The experiment showed that heparin penetrates into the connective tissue of the dermis within 4 hours in a clinically sufficient amount. Deep penetration is ensured by a combination of heparin with Serae bulb extract and allantoin (transepidermal heparinization).
When using the drug Contractubex, systemic absorption is not observed.

Special instructions

To enhance the effect of the drug, apply to pre-steamed skin. It can be used in combination with physiotherapeutic measures.

When treating fresh scars, avoid ultraviolet irradiation, exposure to cold and intense massage.

The effect of the drug during pregnancy, breastfeeding and in children under 1 year of age has not been studied.

Impact on the ability to drive vehicles and machinery
No effect.

Active ingredient

Allantoin, Sodium Heparin, Onion bulb extract

Composition

Per 100 g of gel

Active ingredients: Liquid onion bulb extract 10 g, Sodium heparin 0.04 g (5000 IU), Allantoin 1 g

Excipients: Sorbic acid 0.1 g, Methyl parahydroxybenzoate 0.15 g, Xanthan gum (xanthural 75) 2 g, Macrogol 200 (Polyethylene glycol 200) 25 g, Flavored oil (aroma 231616) 0.3 g, Purified water 61.41 g

Contraindications

Hypersensitivity to the components of the drug, pregnancy, breastfeeding, children under 1 year of age.

Side Effects

Contractubex is usually very well tolerated, even with long-term use.

Most often, skin reactions were observed at the site of application.

Classification of the frequency of occurrence of adverse reactions: very often (> 1/10), often (> 1/100 to 1/1000 to 1/10000 to <1/1000), very rare (< 1/10000), frequency not established (currently there are no data on the prevalence of adverse reactions).From the skin: often: itching, erythema, telangiectasia, scar atrophy; uncommon: skin hyperpigmentation, skin atrophy.The following spontaneous adverse reactions have also been reported:Infectious diseases: frequency not established: pustular rashes.
From the immune system: frequency not established: hypersensitivity (allergic reactions).
From the nervous system: frequency not established: paresthesia.
From the skin: frequency not established: urticaria, rash, itching, erythema, skin irritation, papules, burning sensation, tension, contact dermatitis.

General disorders and disorders at the application site: frequency not established: swelling, pain and peeling at the application site.

Itching, which is a manifestation of natural processes during scar formation, usually does not require discontinuation of the drug.

If any of the side effects indicated in the instructions worsen, or any other side effects not specified in the instructions are noted, you should immediately inform your doctor.

Interaction

Not described.

Overdose

Not described.

Storage conditions

At a temperature not exceeding 25 ° C in a dry place. Keep out of the reach of children.

Shelf life

3 years.
6 months from the moment the tube is opened. Do not use after expiration date.

Manufacturer

Merz Pharma GmbH & Co. KGaA, Germany