Coldrex HotRem, menthol and honey lemon 5 g sachet 10 pcs
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Paracetamol is an analgesic and antipyretic. Its mechanism of action is presumably the inhibition of prostaglandin synthesis, mainly in the CNS.
Paracetamol has almost no effect on the synthesis of prostaglandins in the peripheral tissues, it does not alter the water-electrolyte metabolism and does not damage the mucous membrane of the gastrointestinal tract.
Phenylephrine hydrochloride is a sympathomimetic agent intended to stimulate adrenoreceptors (primarily α-adrenoreceptors), which leads to reduction of nasal mucosa edema and facilitation of nasal breathing.
Ascorbic acid (vitamin C) replenishes the increased demand for vitamin C during “colds” and flu, especially during the initial stages of the disease.
The components of the drug do not cause drowsiness and do not disturb concentration.
Indications
In adults (including elderly patients) and children over 12 years of age to relieve symptoms of “colds” and flu, including:
high body temperature; headache; chills; joint and muscle pain; sinus pain; nasal congestion; sore throat.
How to take, the dosage
For oral administration.
Do not exceed the specified dose.
The smallest dose necessary to achieve the effect should be used.
The minimum interval between doses of Coldrex® HotRem Menthol and Honey Lemon should be 4 hours.
Place the contents of one sachet in a mug and pour half a mug of hot water. Stir until dissolved. Add cold water, if necessary, and sugar to taste.
Adults (including elderly) and children over 12 years: single dose – 1 sachet. The drug may be used again not earlier than 4-6 hours and not more than 4 times a day. The maximum daily dose should not exceed 4 sachets.
The maximum duration of the drug without consulting a doctor is not more than 5 days.
Interaction
Paracetamol when taken for a long time increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Episodic administration of a single dose of the drug has no significant effect on the effect of indirect anticoagulants.
Inducers of enzymes of microsomal oxidation in the liver (barbiturates, diphenine, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effect in overdose and concomitant use with paracetamol. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.
Paracetamol reduces the effectiveness of diuretics. Paracetamol reduces the effectiveness of uricosuric drugs.
Metoclopramide and domperidone increase, and colestyramine reduces the absorption rate of paracetamol.
Paracetamol increases the effects of MAO inhibitors, sedatives, ethanol.
Phenylephrine when taken with MAO inhibitors can lead to high blood pressure. Phenylephrine reduces the effectiveness of beta-adrenoblockers and other hypotensive drugs, increases the risk of hypertension and cardiovascular disorders. Tricyclic antidepressants increase the sympathomimetic effect of phenylephrine, simultaneous use of halothane with phenylephrine increases the risk of ventricular arrhythmia. Phenylephrine reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenergic stimulating activity of phenylephrine.
Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth and constipation.
Concomitant use of glucocorticosteroids with phenylephrine increases the risk of glaucoma.
Concomitant use of digoxin and other cardiac glycosides increases the risk of cardiac arrhythmias and heart attacks.
Concomitant use of phenylephrine with sympathomimetic amines may increase the risk of cardiovascular side effects.
Ascorbic acid increases the risk of crystalluria during treatment with salicylates and sulfonamides of short action, slows renal excretion of acids, increases excretion of drugs with alkaline reaction (including alkaloids).
Ethanol promotes acute pancreatitis.
Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.
Special Instructions
The drug should not be taken simultaneously with other paracetamol-containing drugs, as well as other non-narcotic analgesics, NSAIDs (sodium metamisole, acetylsalicylic acid, ibuprofen, etc.).), drugs to eliminate the symptoms of “colds”, sympathomimetics, such as decongestants, with drugs that regulate appetite, amphetamine-like psychostimulants, barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.
To avoid toxic liver damage the drug should not be combined with ethanol-containing drugs.
During uric acid and blood glucose tests inform the physician about the use of the drug “Coldrex HotRem”, because the drug may distort the results of laboratory tests that assess the concentration of glucose and uric acid.
For patients suffering from phenylketonuria the drug is not recommended, because it contains aspartame, which is a source of phenylalanine.
Before taking the drug “Coldrex HotRem” it is necessary to consult with your doctor, if you are taking it:
warfarin or other indirect anticoagulants for blood thinning;
blood pressure control medications such as beta-adrenoblockers;
digoxin or other cardiac glycosides for heart failure;
appetite-reducing drugs or psychostimulants;
medications to treat depression (tricyclic antidepressants – amitriptyline);
metoclopramide, domperidone (used to eliminate nausea and vomiting) or colestyramine used to reduce blood cholesterol;
if it is necessary to maintain a hyponatremic diet (each bag contains 0.12 g of sodium).
Influence on the ability to drive vehicles and engage in other activities that require concentration and rapid psychomotor reactions:
Does not (when taken in the recommended doses). In case of dizziness it is not recommended to drive vehicles or work with mechanisms.
Synopsis
Powder for preparation of oral solution from almost white to light brown color, loose, heterogeneous, with a smell of honey, lemon and menthol; prepared solution – brownish-orange color, cloudy, without surface foam, with a strongly pronounced smell of honey, lemon and menthol; the solution may contain a small amount of sediment.
Contraindications
- High sensitivity to any component of the drug;
- Extreme hepatic and renal dysfunction;
- hyperthyroidism (incl.hyperthyroidism (including thyrotoxicosis);
- sugar diabetes and sugar/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (because the drug contains sucrose
- heart disease (severe aortic stenosis, acute myocardial infarction, tachyarrhythmia);
- current use of tricyclic antidepressants, beta-adrenoblockers, monoamine oxidase inhibitors (MAOIs), including.ч. up to 14 days after their withdrawal;
- Current use of other paracetamol-containing medications and medications to relieve symptoms of “colds”, flu, and nasal congestion;
- prostate hyperplasia;
- closed-angle glaucoma;
- under 12 years of age.
With caution:
in glucose-6-phosphate dehydrogenase deficiency, in benign hyperbilirubinemia; in liver or kidney disease;
in high blood pressure, heart disease, obliterating vascular disease (Raynaud’s syndrome), glaucoma (excluding closed-angle glaucoma), pheochromocytoma. If you have one of the above diseases, always consult your doctor before taking the drug.
Overdose
If an overdose is suspected, even if you feel well, discontinue use and seek medical attention immediately.
Pregnancy use
Caution should be exercised when pregnant and during breast-feeding.
Pregnancy
The drug should not be used during pregnancy without prior consultation with a physician.
In experimental studies conducted on animals and in clinical trials in humans no risks of paracetamol use during pregnancy or adverse effects on fetal development were revealed.
There is no sufficient data on the effect of drugs containing phenylephrine on pregnancy.
Breast-feeding
The drug should not be used during breast-feeding without prior consultation with a physician.
Paracetamol penetrates the placental barrier, excreted with the breast milk. Clinical studies in humans have shown no adverse effects on the child during breastfeeding.
Phenylephrine may be excreted with breast milk.
Weight | 0.083 kg |
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Shelf life | 2 years. |
Conditions of storage | The drug should be kept out of reach of children at a temperature not exceeding 30 ° C. |
Manufacturer | SmithKlein Beecham S.A., Spain |
Medication form | powder |
Brand | SmithKlein Beecham S.A. |
Other forms…
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