Cofetamine, 10 pcs.

Indications

Migraine, arterial hypotension.

Active ingredient

Composition

– ergotamine tartrate 1 mg
– caffeine 100 mg

Excipients:

Potato starch-0.0238,

Talc-0.0031g,

calcium stearate-0.0006g

Shell excipients;

refined sugar (sucrose) – 0.1346 g,

dextrose monohydrate-0.0207 g,

Potato starch -0.0647g,

talc -0.0072g,

calcium stearate – 0.0028g.

How to take, the dosage

Over the mouth, adults and children over 12 years old take 1-2 tablets at a time of a headache attack, then 1 tablet 2-3 times a day for several days.

The maximum single dose of Cofetamine is 2 tablets, the daily dose is 4 tablets.

Long-term use is not recommended (to avoid ergotism): after 7 days of use, a break is taken (for 3-4 days) in cases that require longer treatment.

Interaction

Enhances the pharmacological effects of other drugs containing ergot alkaloids and caffeine.

It enhances the pharmacological effects of other drugs containing ergot alkaloids and caffeine.

Caffeine is an adenosine antagonist (high doses of adenosine may be required).

When caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) are used together they may increase caffeine metabolism and clearance; cimetidine, oral contraceptive drugs, disulfiram, ciprofloxacin, norfloxacin decrease caffeine metabolism in liver (slowing of its excretion and increasing of blood concentration).

Medications causing CNS stimulation – overstimulation of the CNS is possible.

Mexiletine reduces caffeine excretion by up to 50%; nicotine increases caffeine excretion rate.

MAO inhibitors, furazolidone, procarbazine, and selegiline – large doses of caffeine can cause dangerous cardiac arrhythmias or markedly increased BP.

Caffeine reduces absorption of Ca2+ drugs in the gastrointestinal tract.

Decreases the effect of narcotic analgesics and hypnotics; increases the effect of non-narcotic analgesics (increased absorption).

Increases excretion of Li+ drugs in the urine.

Accelerates absorption and enhances the effect of cardiac glycosides and increases their toxicity.

The co-administration of caffeine with beta-adrenoblockers and may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators – to additional CNS stimulation and other additive toxic effects.
Caffeine may decrease clearance of theophylline and possibly other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

The vasoconstrictor effects of the drug are enhanced by alpha-adrenergic stimulants, beta-adrenoblockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase the toxicity of ergotamine (decreased hepatic clearance of caffeine).

Special Instructions

Impact on the ability to drive

Period of treatment, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities that require concentration and quick psychomotor reactions.

Contraindications

Individual intolerance to the ingredients of the drug, children under 12 years of age.

. With caution – sleep disorders, anxiety disorders (agoraphobia, panic disorder), organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, significant atherosclerosis, paroxysmal tachycardia, frequent ventricular extrasystoles, arterial hypertension, obliterating diseases of peripheral vessels), hepatic and/or renal failure, glaucoma, advanced age.

Side effects

Nervous system disorders: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesias in the extremities, increased reflexes, tachypnoea, insomnia; in sudden withdrawal – increased central nervous system inhibition, increased fatigue, sleepiness.

Cardiovascular system disorders: palpitations, tachycardia, cardialgia, increased blood pressure.

Digestive system disorders: nausea, vomiting, diarrhea.

Allergic reactions: edema, skin itching.

Others: with long-term use – addiction, drug dependence, weakness in the legs, myalgia, Lerish syndrome (severe cyanosis, no pulse in the lower extremities, pain, distal sensory disorders).

Overdose

Symptoms: increased severity of side effects, including nausea, vomiting, numbness of fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma.

Treatment: gastric lavage, activated charcoal administration, if necessary – symptomatic therapy.