Clenzit-S, gel 30 g

Klenzit C Gel is a combination medicine for the treatment of acne (acne), topical application. The active ingredients are Adapalene and Clindamycin.

The retinoid derivative, Adapalene, has anti-inflammatory and comedolytic activity. It has an effect on open and closed comedones and helps normalize the processes of epidermal differentiation and keratinization.

The drug reduces the moment of binding of follicular epithelium cells which contribute to formation of microcomedones and also inhibits chemokinetic reactions and chemotaxis of polynuclear cells.

The antimicrobial agent clindamycin belongs to the group of lincosamides and has bacteriostatic activity against many microorganisms. Clindamycin binds to 50S subunit of ribosomal membranes and inhibits protein replication in the bacterial cell.

It also has a bactericidal effect against some Gram-positive cocci.

In therapy with Clenzit C patients with acne decrease the intensity of inflammation, acne reduction and decrease of comedones and overall improvement of facial skin condition.

In connection with external use of Clensit C, its systemic absorption is insignificant.

Indications

Treatment of acne (acne disease).

Pharmacological effect

Gel Klenzit S is a combined drug for the treatment of acne (acne), for local use. The active substances are Adapalene and Clindamycin.

A retinoid derivative, Adapalene, exhibits anti-inflammatory and comedolytic activity. It has an effect on open and closed comedones, helps normalize the processes of epidermal differentiation and keratinization.

The drug reduces the moment of binding of follicular epithelial cells, which contribute to the formation of microcomedones, and also inhibits chemokinetic reactions and chemotaxis of polynuclear cells.

The antimicrobial agent Clindamycin belongs to the group of lincosamides and has bacteriostatic activity against many microorganisms. Clindamycin binds to the 50S subunit of ribosomal membranes, inhibiting protein replication in the bacterial cell.

It also exhibits a bactericidal effect against some gram-positive cocci.

When therapy is carried out with the use of Klenzit S, patients with acne experience a decrease in the intensity of inflammation, a decrease in acne elements, as well as a decrease in the number of comedones and a general improvement in the condition of the facial skin.

Due to the external use of the drug Klenzit S, its systemic absorption is negligible.

Special instructions

In the initial stages of treatment, an exacerbation of acne may occur, which disappears during the treatment process.

If skin irritation occurs, stop using the gel (temporarily or permanently). Avoid exposure to the sun and the use of artificial UV radiation (solarium).

If prolonged exposure to the sun is necessary, do not apply the gel the day before and the day after sun exposure.

Do not simultaneously use cosmetics with a drying or irritating effect (for example, cologne or products containing ethanol). The use of the gel to treat damaged skin and burns is not allowed.

Active ingredient

Adapalene, Clindamycin

Composition

Active ingredients:

Adapalene (micronized) 1 mg;

Clindamycin (as phosphate) 10 mg.

Excipients:

Disodium edetate;

Carbomer 940 (Carbopol 940);

Propylene glycol;

Methyl parahydroxybenzoate;

Phenoxyethanol;

Poloxamer 407;

Sodium hydroxide;

Purified water.

Contraindications

hypersensitivity to Adapalene, Clindamycin and other ingredients of the drug;
lactation period;
pregnancy period.

Use with caution for eczema and dermatitis.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C (do not freeze)

Shelf life

2 years

Manufacturer

Glenmark Pharmaceuticals Ltd, India