Clenzit-S, gel 15 g

Klenzit C Gel is a combination medicine for the treatment of acne (acne), topical application. The active ingredients are Adapalene and Clindamycin.

The retinoid derivative, Adapalene, has anti-inflammatory and comedolytic activity. It has an effect on open and closed comedones and helps normalize the processes of epidermal differentiation and keratinization.

The drug reduces the moment of binding of follicular epithelial cells which promote formation of microcomedones and also inhibits chemokinetic reactions and chemotaxis of polynuclear cells.

The antimicrobial agent clindamycin belongs to the group of lincosamides and has bacteriostatic activity against many microorganisms. Clindamycin binds to the 50S subunit of the ribosomal membrane and inhibits protein replication in the bacterial cell.

It also has a bactericidal effect against some Gram-positive cocci.

In therapy with Klensit C patients with acne decrease the intensity of inflammation, acne cells decrease, as well as decrease the number of comedones and the general improvement of facial skin condition.

In connection with external use of Clensit C its systemic absorption is insignificant.

Indications

Common acne (vulgar)

Acne (acne disease) treatment.

Active ingredient

Adapalene, Clindamycin

Composition

Active ingredients:

Adapalen (micronized) 1 mg,

clindamycin (in the form of phosphate) 10 mg.

Excipients:

dinatrium edetate,

carbomer 940 (carbopol 940),

propylene glycol,

methylparahydroxybenzoate,

phenoxyethanol,

poloxamer 407,

sodium hydrochloride,

purified water.

How to take, the dosage

Clenzit-S is used externally. Before applying the gel it is necessary to clean and dry the skin.

With a light touch apply Klensit-S gel evenly to the affected areas of the skin once a day before bedtime. Avoid contact of the drug with the mucous membranes of the eyes and lips.

The course of treatment is from 2 to 4 weeks. The course of treatment can be repeated after consulting the doctor.

Interaction

There have been no studies of interaction with other medicinal products. However, other retinoids or external antibiotics or drugs with a similar mechanism of action should not be used concomitantly.

Perhaps caution should be exercised when using cosmetic products with exfoliating irritant or drying effects at the same time, due to the possible additional irritant effect.

The absorption of adapalene through the skin is low, so the development of interactions with drugs of systemic action is unlikely.

After external use of clindamycin very low concentrations of clindamycin are determined in the blood serum and urine. There is cross-resistance of microorganisms to clindamycin and lincomycin. Antagonism between clindamycin and erythromycin has been noted. It was found that clindamycin interferes with neuromuscular transmission and therefore can enhance the effect of other peripheral myorelaxants therefore the drug should be used with caution in patients receiving this group of drugs.

The simultaneous use of the drug with drugs containing erythromycin is not recommended.

Special Instructions

In the initial stages of treatment, there may be an aggravation of acne that disappears in the course of treatment. If skin irritation occurs, discontinue use of the gel (temporarily or permanently).

Avoid contact with the eyes, mouth, nose and other mucous membranes. If the drug accidentally gets into the eyes, the mouth or nose should be rinsed immediately with warm water.

Excessive exposure to sunlight or ultraviolet radiation should be avoided. If you have been in the sun for an extended period of time, do not apply the gel the day before and the day of sun exposure and the day after.

The simultaneous use of cosmetic products with drying or irritating properties (e.g., cologne, perfume, and other ethanol-containing products) is not recommended.

If clindamycin is used topically, cases of diarrhea and colitis are extremely rare, however, caution should be exercised and if severe or prolonged diarrhea develops, the drug should be discontinued and appropriate diagnostic and treatment measures taken if necessary. Pseudomembranous colitis may appear both during long-term use and 2-3 weeks after discontinuation of the treatment; it is manifested by diarrhea, leukocytosis, fever, abdominal pain (sometimes accompanied by fecal discharge of blood and mucus).

When these phenomena occur in mild cases, withdrawal of treatment and use of ion-exchange resins (colestiramine colestipol) in severe cases compensation for fluid loss of electrolytes and protein is indicated with oral vancomycin or metronidazole administration. Do not use agents that inhibit intestinal peristalsis.

Influence on the ability to operate vehicles and machinery:

Have not been studied.

Contraindications

• hypersensitivity to Adapalen, Clindamycin and other ingredients of the drug
• lactation period
• pregnancy period.

With caution use in eczema and dermatitis.

Side effects

Skin and subcutaneous fat: dry skin irritation burning sensation erythema contact dermatitis discomfort feeling sunburn at the site of application skin peeling skin soreness swollen skin increased sebum production urticaria.

Overlooking organs: eyelid irritation itching swollen eyelids erythema in the eyelid area burning sensation in the eyes.

Digestive system: abdominal pain gastrointestinal disorders (diarrhea nausea vomiting).

Others: allergic reactions folliculitis caused by gram-negative flora may develop pseudomembranous colitis.

If skin irritation develops, treatment should be stopped until the irritation subsides or the frequency of use is reduced.

Check with your doctor if you experience any of the side effects mentioned or other side effects not listed above.

Overdose

Adapalen overdose is unlikely.

In external use clindamycin may be absorbed in amounts causing systemic effects. In case of overdose symptomatic and supportive therapy is indicated.

In case of accidental ingestion of the drug the stomach should be flushed and the patient should immediately consult a physician.

Pregnancy use

During pregnancy and breastfeeding the use of the drug is contraindicated.