Clenbuterol, 1 mcg/ml syrup 100 ml

Clenbuterol belongs to the group of selective β₂-adrenomimetics. Clenbuterol is a drug with rapid bronchodilator action. Its action is due to the specific stimulation of β₂ -adrenoreceptors of smooth muscles. Binding to them activates the enzyme adenylate cyclase, which leads to increased intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to bind to actin, resulting in relaxation of the bronchi. Clenbuterol stimulates bronchial mucosal cells and increases expectoration. In prescribed therapeutic doses, clenbuterol has no effect on heart rate and blood pressure.

Indications

Bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema and other lung diseases with bronchoobstructive syndrome.

Active ingredient

Clenbuterol

Composition

1 ml of syrup contains clenbuterol hydrochloride 0.001 mg (1 dosage spoon = 5 ml – 0.005 mg).

How to take, the dosage

The drug is taken orally.

The daily dose for children from 6 to 12 years of age (body weight 22-35 kg) is 15 mcg (in 2 doses).

Adults and children over 12 years of age: 2 doses of 10-20 mcg daily.

The maintenance dose is 2 times 10 mcg.

The duration of treatment with Clenbuterol is 2-3 days, until the acute symptoms have disappeared.

The duration of maintenance therapy should not exceed 7 days. The decision to treat for a period longer than 7 days is made by the treating physician.

Interaction

Beta-adrenoblockers inhibit the effect of Clenbuterol, and there is a risk of bronchospasm when taking them concomitantly.

The use of the drug simultaneously with hypoglycemic agents reduces their effect.

Clenbuterol increases the effects and side effects of beta-adrenomimetics, theophylline and anticholinergic agents.

The simultaneous use of clenbuterol and halogenated hydrocarbons for anesthesia (in manipulations and interventions) has an increased risk of arrhythmia.

Clenbuterol can be used concomitantly with diuretics and cardiac glycosides, but with periodic monitoring of serum electrolytes.

In concomitant use with monoamine oxidase inhibitors (tricyclic antidepressants), cardiac arrhythmias may occur.

Special Instructions

The drug contains so-called parabens as excipients: methyl parahydroxybenzoate and propyl parahydroxybenzoate, which may cause urticaria and contact dermatitis (delayed-type allergic reactions). Rarely, allergic reactions of the immediate type (bronchospasm) may occur.

The drug contains glycerol as an excipient, which in high doses may cause headache, stomach irritation and diarrhea.

The product has 0.63 vol.% ethyl alcohol. Each dose contains 0.005 g of alcohol in 1 ml. It is dangerous for people with liver diseases, alcoholism, epilepsy, brain lesions or diseases, as well as for pregnant women and children. May increase the effect of other drugs.

The drug is not suitable for patients with a congenital intolerance to fructose because of the presence of sorbitol.

Impact on driving and operating machinery

In the first days of treatment, clenbuterol may cause slight tremors and restlessness, which requires increased caution when driving and operating machinery.

Features

Intestation and distribution

Clenbuterol is absorbed relatively quickly in the gastrointestinal tract.

The binding to plasma proteins is 89-98%.

Metabolism and excretion

The biological T_1/2 is 3.5 h. It is excreted mainly through the kidneys as sulfoconjugated derivatives.

Contraindications

• thyrotoxicosis;
• hypertrophic obstructive cardiomyopathy;
• closed angle glaucomaclosed-angle glaucoma;
• pheochromocytoma;
• tachyarrhythmia;
• myocardial infarction (acute period);
• pregnancy (first and third trimester);
• lactation period;
• children under 6 years of age;
• hypersensitivity to the active or to any of the excipients.

With caution in the following cases: immediately after myocardial infarction, in hepatic and renal insufficiency, heart rhythm disorders, myocarditis, mitral valve defects, hypokalemia, unstable or uncompensated diabetes.

Side effects

Muscular system: fine muscle tremors.

CNS: restlessness, headache.

Cardiovascular system: decreased or increased blood pressure, tachycardia, angina pains, ventricular extrasystoles.

Skin and mucous membranes: skin rash, facial edema, urticaria.

Circulatory system: thrombocytopenia, hypoglycemia.

Gastrointestinal system: gastritis, diarrhea, dry mouth, nausea.

Genital system: impaired urination.

The described adverse reactions go away without stopping the treatment, 1-2 weeks after starting it.

Overdose

Symptoms: hand tremors, increased sweating, headache, tachycardia. In particularly severe cases of overdose of this drug collapse, seizures and coma are possible.

Emergency measures: in all cases of overdose the use of clenbuterol is stopped. Gastric lavage is performed, activated charcoal is administered, forced diuresis is performed and symptomatic treatment is started. The use of clenbuterol syrup in doses exceeding the recommended ones may lead to a worsening of the course of bronchial asthma. In such cases, immediate consultation with a physician and, if necessary, hospitalization is necessary.