Clenbuterol, 1 mcg/ml syrup 100 ml

Clenbuterol belongs to the group of selective β₂-adrenomimetics. Clenbuterol is a drug with rapid bronchodilator action. Its action is due to the specific stimulation of β₂ -adrenoreceptors of smooth muscles. Binding to them activates the enzyme adenylate cyclase, which leads to increased intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to bind to actin, resulting in relaxation of the bronchi. Clenbuterol stimulates bronchial mucosal cells and increases expectoration. In prescribed therapeutic doses, clenbuterol has no effect on heart rate and blood pressure.

Indications

Bronchial asthma, chronic obstructive bronchitis, emphysema and other lung diseases with broncho-obstructive syndrome.

Pharmacological effect

Clenbuterol belongs to the group of selective β2-adrenergic agonists. Clenbuterol is a drug that has a rapid bronchodilator effect. Its action is due to the specific stimulation of β2 adrenergic receptors of smooth muscles. When bound to them, the enzyme adenylate cyclase is activated, which leads to an increase in the intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to connect with actin, resulting in relaxation of the bronchi. Clenbuterol stimulates the cells of the bronchial mucosa and increases expectoration. At prescribed therapeutic doses, clenbuterol does not affect heart rate or blood pressure.

Special instructions

The drug contains so-called parabens as excipients: methyl parahydroxybenzoate and propyl parahydroxybenzoate, which can cause urticaria and contact dermatitis (delayed allergic reactions). Rarely, immediate allergic reactions (bronchospasm) may occur.

The drug contains glycerol as an excipient, which in high doses can cause headaches, stomach irritation and diarrhea.

The drug contains 0.63 vol.% ethyl alcohol. Each dose contains 0.005 g of alcohol per 1 ml. Dangerous for people with liver disease, alcoholism, epilepsy, brain damage or disease, as well as for pregnant women and children. May enhance the effect of other medications.

The drug is not suitable for patients with congenital fructose intolerance due to the presence of sorbitol.

Impact on the ability to drive vehicles and operate machinery

In the first days of treatment, clenbuterol may cause slight tremor and anxiety, which requires increased caution when driving a car and operating equipment.

Active ingredient

Clenbuterol

Composition

1 ml of syrup contains clenbuterol hydrochloride 0.001 mg (1 dosage spoon = 5 ml – 0.005 mg).

Contraindications

thyrotoxicosis;
hypertrophic obstructive cardiomyopathy;
angle-closure glaucoma;
pheochromocytoma;
tachyarrhythmia;
myocardial infarction (acute period);
pregnancy (I and III trimester);
lactation period;
children under 6 years of age;
hypersensitivity to the active substance or to any of the excipients.

With caution in the following cases: immediately after a myocardial infarction, with liver and kidney failure, heart rhythm disturbances, myocarditis, mitral valve defects, hypokalemia, unstable or uncompensated diabetes.

Side Effects

Muscular system: fine muscle tremors.

CNS: anxiety, headache.

Cardiovascular system: decreased or increased blood pressure, tachycardia, angina pain, ventricular extrasystole.

Skin and mucous membranes: skin rash, facial swelling, urticaria.

Circulatory system: thrombocytopenia, hypoglycemia.

Gastrointestinal tract: gastritis, diarrhea, dry mouth, nausea.

Genitourinary system: urinary disturbance.

The described adverse reactions disappear without stopping treatment, 1-2 weeks after its start.

Interaction

Beta-blockers suppress the effect of Clenbuterol, and when taken simultaneously, there is a risk of developing bronchospasm.

Use of the drug simultaneously with hypoglycemic agents reduces their effect.

Clenbuterol enhances the effect and side effects of beta-agonists, theophylline and anticholinergics.

With the simultaneous use of clenbuterol and halogenated hydrocarbons for anesthesia (during manipulations and interventions), there is an increased risk of arrhythmia.

Clenbuterol can be used simultaneously with diuretics and cardiac glycosides, but with periodic monitoring of serum electrolytes.

When used simultaneously with monoamine oxidase inhibitors (tricyclic antidepressants), heart rhythm disturbances are possible.

Overdose

Symptoms: tremor of the fingers, increased sweating, headache, tachycardia. In particularly severe cases of overdose of this drug, collapse, convulsions and coma are possible.

Immediate measures: in all cases of overdose, stop taking clenbuterol. Gastric lavage is performed, activated charcoal is administered, forced diuresis is performed and symptomatic treatment is begun. The use of clenbuterol syrup in doses exceeding the recommended ones may lead to a worsening of bronchial asthma. In such cases, immediate consultation with a doctor and, if necessary, hospitalization are necessary.

Functional features

Suction and distribution

Clenbuterol is relatively quickly absorbed from the gastrointestinal tract.

Communication with plasma proteins is 89-98%.

Metabolism and excretion

Biological T1/2 is 3.5 hours. It is excreted mainly through the kidneys in the form of sulfoconjugated derivatives.

Storage conditions

At a temperature not higher than 25°C. Keep out of the reach of children!

Shelf life

3 years

Manufacturer

Sopharma JSC, Bulgaria