Citovir-3, capsules 48 pcs

Pharmacotherapeutic group: immunostimulant.

ATX code: L03AX

Pharmacological properties:

Pharmacodynamics: the drug is a means of etiotropic and immunostimulant therapy, has indirect antiviral action against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases.

In in vitro studies the drug specifically suppresses (inhibits) multiplication (replication) of SARS-CoV-2 virus which is the causative agent of a new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing drug concentration (dose-effect linearity is shown).

Limits the severity of the main clinical symptoms of influenza and acute respiratory infections, as well as reduces the duration of the disease and contributes to its uncomplicated course.

It increases the content of secretory immunoglobulin A (slgA) in the nasopharynx mucosa, the entry gate of infection, increasing the local immunoresistance of the body to respiratory infections of viral and bacterial nature.

In case of preventive action the preparation increases potential metabolic activity of cells of innate immunity (neutrophil granulocytes and monocytes) which in case of development of infection increases their ability to absorb and destroy bacterial and viral agents due to increase of enzymatic (oxidative) activity, synthesis of cationic proteins and increase of the number of phagocytes. At the same time the initial state of the metabolic activity of cells of innate immunity, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces in the body the production of endogenous interferon and has immunomodulatory effects (normalizes the body’s immune response to various infectious agents). Enzymes, production of which is induced by interferon in cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist of immunomodulatory action of bendazole by normalizing the T-cell link of immunity.

Ascorbic acid activates humoral part of the immune system, normalizes capillary permeability, thus reducing inflammation, shows antioxidant properties, neutralizing oxygen radicals accompanying the inflammatory process, increases resistance to infection.

Pharmacokinetics: when administered orally the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan – not more than 15%, ascorbic acid – up to 90%. Metabolites of ascorbic acid and bendazole are excreted with urine. Alpha-glutamyl-tryptophan under the influence of peptidases is split into L-glutamic acid and L-tryptophan, which are used by the body in peptide synthesis.

Indications

Prevention and complex therapy of influenza and acute respiratory viral infections in adults and children over 6 years of age.

Pharmacological effect

Pharmacotherapeutic group: immunostimulating agent.

ATX code: L03AX

Pharmacological properties:

Pharmacodynamics: the drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases.

In in vitro studies, the drug specifically suppresses (inhibits) the reproduction (replication) of the SARS-CoV-2 virus, which is the causative agent of the new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing concentration of the drug (the linearity of the dose-effect relationship is shown).

Reduces the severity of the main clinical symptoms of influenza and ARVI, and also shortens the duration of the disease and promotes its uncomplicated course.

Increases the content of secretory immunoglobulin A (slgA) in the mucous membrane of the nasopharynx – the entrance gate of infection, increasing the local immunoresistance of the body to respiratory infections of a viral and bacterial nature.

With a preventive effect, the drug increases the potential metabolic activity of innate immune cells (neutrophil granulocytes and monocytes), which, in the event of an infection, increases their ability to absorb and destroy bacterial and viral agents due to increased enzymatic (oxidative) activity, synthesis of cationic proteins and an increase in the number of phagocytic cells. In this case, the initial state of metabolic activity of innate immune cells, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces the body’s production of endogenous interferon and has an immunomodulatory effect (normalizes the body’s immune response to various infectious agents). Enzymes, the production of which is induced by interferon in the cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist for the immunomodulatory effect of bendazole, normalizing the T-cell component of immunity.

Ascorbic acid activates the humoral component of the immune system, normalizes capillary permeability, thereby reducing inflammation, exhibits antioxidant properties, neutralizing oxygen radicals that accompany the inflammatory process, and increases the body’s resistance to infection.

Pharmacokinetics: when taken orally, the drug is completely absorbed from the gastrointestinal tract.
tract. The bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan is not
more than 15%, ascorbic acid – up to 90%. Metabolites of ascorbic acid and
bendazole is excreted in the urine. Alpha-glutamyl-tryptophan under the influence of peptidases
is broken down into L-glutamic acid and L-tryptophan, which are used by the body in peptide synthesis.

Special instructions

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Alpha Glutamyl, Tryptophan, Ascorbic Acid, Bendazole

Composition

For one capsule

Active substances:

Alpha-glutamyl-tryptophan sodium (Thymogen® sodium) – 0.5 mg,

Ascorbic acid – 50 mg,

Bendazole hydrochloride (Dibazol) – 20 mg,

Excipients:

Lactose monohydrate – 97.8 mg,

Calcium stearate – 1.7 mg

Composition of the capsule shell: Body: titanium dioxide 2%, gelatin up to 100%.

Cap: titanium dioxide 2%, sunset yellow dye 0.2190%, azorubine dye 0.0328%, gelatin up to 100%.

Pregnancy

The drug is contraindicated for use during pregnancy.

During breastfeeding, use is possible if the expected benefit to the mother outweighs the potential risk to the child.

Use in children

Contraindications: children under 6 years of age.

Contraindications

Hypersensitivity to the components of the drug, pregnancy, children under 6 years of age.

With caution: during breastfeeding, use is possible if the expected benefit to the mother outweighs the potential risk to the child.

Side Effects

Allergic reactions, short-term decrease in blood pressure.

Interaction

No interaction of alpha-glutamyl-tryptophan with drugs has been identified.

Bendazole prevents the increase in total peripheral vascular resistance caused by the use of non-selective beta-blockers. Strengthens the hypotensive (lowering blood pressure) effect of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole.

Ascorbic acid increases the concentration in the blood of antibacterial drugs of the tetracycline series and benzylpenicillin. Improves the absorption of iron (Fe) preparations in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce its absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Ascorbic acid increases the risk of developing crystalluria when using drugs containing acetylsalicylic acid (ASA) and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration in the blood of oral contraceptives. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Possible simultaneous use with antiviral drugs and symptomatic treatment of influenza and ARVI.

Consult your doctor if you are taking the medications listed in this section or other medications.

Overdose

Symptoms: short-term decrease in blood pressure in elderly patients with vegetative-vascular dystonia. Monitoring of kidney function, blood pressure and blood glucose concentrations is necessary.

Storage conditions

At a temperature not higher than 25 oC. Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Manufacturer

Cytomed MBNPK, Russia