Citovir-3, capsules 12 pcs.

Pharmacotherapeutic group: immunostimulant.

ATX code: L03AX

Pharmacological properties:

Pharmacodynamics: the drug is a means of etiotropic and immunostimulant therapy, has indirect antiviral action against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases.

In in vitro studies the drug specifically suppresses (inhibits) multiplication (replication) of SARS-CoV-2 virus which is the causative agent of a new coronavirus infection (COVID-19).

The degree of inhibition of the pathogen increases with increasing drug concentration (dose-effect linearity is shown).

Limits the severity of the main clinical symptoms of influenza and acute respiratory infections, as well as reduces the duration of the disease and contributes to its uncomplicated course.

It increases the content of secretory immunoglobulin A (slgA) in the nasopharynx mucosa – the entrance gate of infection, increasing the local immunoresistance of the body to respiratory infections of viral and bacterial nature.

In case of preventive action the preparation increases potential metabolic activity of cells of innate immunity (neutrophil granulocytes and monocytes) which in case of development of infection increases their ability to absorb and destroy bacterial and viral agents due to increase of enzymatic (oxidative) activity, synthesis of cationic proteins and increase of the number of phagocytes. At the same time the initial state of the metabolic activity of cells of innate immunity, in the absence of infectious agents, does not change, being within normal values.

Bendazole induces in the body the production of endogenous interferon and has immunomodulatory effects (normalizes the body’s immune response to various infectious agents). Enzymes, production of which is induced by interferon in cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist of immunomodulatory action of bendazole by normalizing the T-cell link of immunity.

Ascorbic acid activates the humoral part of the immune system, normalizes capillary permeability, thus reducing inflammation, shows antioxidant properties, neutralizing oxygen radicals accompanying the inflammatory process, increases resistance to infection.

Pharmacokinetics: when administered orally the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan – not more than 15%, ascorbic acid – up to 90%. Metabolites of ascorbic acid and bendazole are excreted with urine. Under the influence of peptidases alpha-glutamyl-tryptophan is split into L-glutamic acid and L-tryptophan, which are used by the body in peptide synthesis.

Indications

Prevention and comprehensive treatment of flu and acute respiratory viral infections in adults and children over 6 years.

Composition

In one capsule

The active ingredients:

Alpha-glutamyl-tryptophan sodium (Timogen® sodium) – 0.5 mg,

Ascorbic acid – 50 mg,

Bendazol hydrochloride (Dibasol) – 20 mg,

Additional substances:

Lactose monohydrate – 97.8 mg,

Calcium stearate – 1.7 mg

Capsule shell composition: Case: titanium dioxide 2%, gelatin to 100%.

Caps: titanium dioxide 2%, sunset yellow dye 0.2190%, azorubin dye 0.0328%, gelatin to 100%.

How to take, the dosage

Ingestion, 30 minutes before a meal. Single dose for adults and children over 6 years – 1 capsule.

For treatment:

One capsule 3 times a day for 4 days.

For prevention:

– In direct contact with a patient with influenza and other acute respiratory infections, one capsule 3 times a day for 4 days.

– during the epidemic rise in the incidence of influenza and other acute respiratory infections, one capsule 1 time a day for 12 days.

The prophylactic course, if necessary, is repeated in 3 weeks (until the normalization of the epidemic situation).

Interaction

Interaction of alpha-glutamyl-tryptophan with drugs has not been identified.

Bendazole prevents an increase in total peripheral vascular resistance due to the use of non-selective beta-adrenoblockers. It enhances the hypotensive (decrease in blood pressure) effect of hypotensive and diuretic drugs. Phentolamine increases the hypotensive effect of bendazole.

Ascorbic acid increases the concentration in the blood of antibacterial agents of the tetracycline series and benzylpenicillin. Improves absorption of iron (Fe) in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinking reduce its absorption and assimilation. When concomitant use with ASA, urinary excretion of ascorbic acid is increased and excretion of ASA is reduced. ASA reduces absorption of ascorbic acid by about 30%. Ascorbic acid increases the risk of crystalluria when using drugs containing acetylsalicylic acid (ASA) and short-acting sulfonamides, delays renal excretion of acids, increases excretion of drugs with an alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives. Concomitant use reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase excretion of ascorbic acid with urine.

Possible concomitant use with antiviral drugs and agents of symptomatic therapy of influenza and acute respiratory infections.

Consult your physician if you are taking the medications listed in the section or other medications.

Special Instructions

The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

With caution: during breastfeeding the use is possible if the estimated benefit to the mother is greater than the potential risk to the baby.

Side effects

Allergic reactions, short-term decrease in blood pressure.

Overdose

Symptoms: transient decrease of blood pressure in patients with vegetovascular dystonia, elderly. Monitoring of renal function, blood pressure and blood glucose concentration is necessary.