Ciprofloxacin Reneval, eye drops 0.3% 10 ml

Ciprofloxacin is a broad-spectrum antimicrobial from the group of fluoroquinolones. It has a bactericidal effect. The drug inhibits bacterial enzyme DNA-gyrase, as a result DNA replication and synthesis of bacterial cell proteins are disrupted. Ciprofloxacin acts both on multiplying microorganisms and on those which are in the quiescent phase.

The following bacteria are sensitive to Ciprofloxacin:

Gram-negative aerobic bacteria: Escherichia coli, Salmonella spp, Shigella spp, Citrobacter spp, Klebsiella spp, Enterobacter spp, Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp, Morganella mordarii, Vibrio spp, Yersinia spp.
Other Gram-negative bacteria: Haemophilus spp, Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromona, spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neissenia spp.

Some intracellular pathogens: Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium aviumintracellulare.

Gram-positive aerobic bacteria: Staphylococcus spp. (S.haemolyticus, S.hominis, S.saprophyticus), Streptococcus spp. (St. pyogenes, St. agalactiae).

The sensitivity of the bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate. Most staphylococci resistant to methicillin are also resistant to Ciprofloxacin.

Corynebacterium spp, Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia are resistant to the drug.
Ureaplasma, Clostridium difficile.

The action of the drug against Treponema pallidum has not been studied sufficiently.

Indications

Infectious and inflammatory eye diseases (acute and subacute conjunctivitis, blepharitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, bacterial corneal ulcer, meibomitis, acute dacryocystitis, infectious lesions after eye trauma), pre- and postoperative prevention of infectious complications in ophthalmic surgery.

Pharmacological effect

Ciprofloxacin is a broad-spectrum antimicrobial drug from the group of fluoroquinolones. Acts bactericidal. The drug inhibits the enzyme DNA gyrase of bacteria, as a result of which DNA replication and the synthesis of cellular proteins of bacteria are disrupted. Ciprofloxacin acts both on microorganisms that are reproducing and those in the resting phase.

Sensitive to Ciprofloxacin:

Gram-negative aerobic bacteria: Escherichia coli, Salmonella spp, Shigella spp, Citrobacter spp, Klebsiella spp, Enterobacter spp, Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp, Morganella mordarii, Vibrio spp, Yersinia spp.
Other gram-negative bacteria: Haemophilus spp, Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromona spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neissenia spp.

Some intracellular pathogens: Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium aviumintracellulare.

Gram-positive aerobic bacteria: Staphylococcus spp. (S.haemolyticus, S.hominis, S.saprophyticus), Streptococcus spp. (St. pyogenes, St. agalactiae).

The sensitivity of bacteria Streptococcus pneumoniae and Enterococcus faecalis is moderate. Most staphylococci resistant to methicillin are also resistant to ciprofloxacin.

The following are resistant to the drug: Corynebacterium spp, Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia.
Ureaplasma, Clostridium difficile.

The effect of the drug against Treponema pallidum has not been sufficiently studied.

Special instructions

The solution in the form of eye drops is not intended for intraocular injection.

When using other ophthalmic drugs, the interval between their administration should
be at least 15 minutes

Immediately after using the drug, blurred visual perception is possible, which can lead to difficulties when driving vehicles and when working with machinery; It is recommended to start work (driving) 15 minutes after using the drug.

During treatment with the drug, wearing contact lenses is not recommended.
After opening the bottle, the drug should be used for no more than 14 days.

Active ingredient

Ciprofloxacin

Composition

1 ml of solution contains:
active substance:
ciprofloxacin hydrochloride
(in terms of ciprofloxacin) – 3 mg
excipients:
disodium edetate (trilon B) – 0.5 mg
mannitol (mannitol) – 46 mg
sodium acetate – 0.5 mg
acetic acid – 0.0015 ml
benzalkonium chloride – 0.1 mg
water for injection – up to 1 ml

Contraindications

Hypersensitivity to the components of the drug, viral and fungal eye infections, pregnancy, breastfeeding, children under 1 year of age.

With caution:

The solution in the form of eye drops is not intended for intraocular injection.
When using other ophthalmic drugs, the interval between their administration should be at least 15 minutes.

Side Effects

Allergic reactions, itching and burning in the eye, mild pain and hyperemia of the conjunctiva, nausea, rarely – swelling of the eyelids, photophobia, lacrimation, sensation of a foreign body in the eyes, unpleasant taste in the mouth immediately after instillation, decreased visual acuity, the appearance of a white crystalline precipitate in patients with corneal ulcers, keratitis, keratopathy, corneal infiltration, development of superinfection.

Interaction

The interaction of Ciprofloxacin drops with other drugs when used simultaneously has not been detected.

There is evidence that systemic use of some quinolones leads to an increase in the concentration of theophylline in the blood plasma, affects the metabolism of caffeine and enhances the effect of oral anticoagulants such as warfarin and its derivatives. A transient increase in serum creatinine has been reported in patients prescribed cyclosporine with systemic ciprofloxacin.

Ciprofloxacin is incompatible with alkaline solutions.

Overdose

There are no data on drug overdose. If the drug is accidentally taken orally, there are no specific symptoms. Nausea, vomiting, diarrhea, headache, fainting, and anxiety may occur.
Treatment: standard emergency measures, adequate fluid intake, acidification of urine to prevent crystalluria.

Storage conditions

In a place protected from light at a temperature of 15 to 25 ° C.

Avoid freezing.

Keep out of the reach of children.

Shelf life

3 years.

Manufacturer

Update of PFC JSC, Russia