Ciprofloxacin Reneval, eye drops 0.3% 10 ml

Ciprofloxacin is a broad-spectrum antimicrobial from the group of fluoroquinolones. It has a bactericidal effect. The drug inhibits bacterial enzyme DNA-gyrase, as a result DNA replication and synthesis of bacterial cell proteins are disrupted. Ciprofloxacin acts both on multiplying microorganisms and on those which are in the quiescent phase.

The following bacteria are sensitive to Ciprofloxacin:

Gram-negative aerobic bacteria: Escherichia coli, Salmonella spp, Shigella spp, Citrobacter spp, Klebsiella spp, Enterobacter spp, Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp, Morganella mordarii, Vibrio spp, Yersinia spp.
Other Gram-negative bacteria: Haemophilus spp, Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromona, spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neissenia spp.

Some intracellular pathogens: Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium aviumintracellulare.

Gram-positive aerobic bacteria: Staphylococcus spp. (S.haemolyticus, S.hominis, S.saprophyticus), Streptococcus spp. (St. pyogenes, St. agalactiae).

The sensitivity of the bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate. Most staphylococci resistant to methicillin are also resistant to Ciprofloxacin.

Corynebacterium spp, Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia are resistant to the drug.
Ureaplasma, Clostridium difficile.

The action of the drug against Treponema pallidum has not been studied sufficiently.

Indications

Active ingredient

Composition

How to take, the dosage

Topically. The drug is injected 1-2 drops into the conjunctival sac. Frequency of instillation depends on the severity of the inflammatory process.

In acute bacterial conjunctivitis, simple, scaly and ulcerous blepharitis, meibomitis the drug is prescribed 4 to 8 times a day depending on the severity of the disease. The course of treatment is from 5 to 14 days.

In case of keratitis the drug is prescribed in 1 drop at least 6 times a day; with positive effect the maximum course of treatment depending on the severity of corneal damage is about 2-4 weeks.

Interaction

The interaction of Ciprofloxacin drops with other drugs during concomitant use has not been identified.

There is information that systemic use of some quinolones leads to increased plasma concentrations of theophylline, affects caffeine metabolism and enhances the effect of oral anticoagulants such as warfarin and its derivatives. a temporary increase in serum creatinine was reported in patients who received cyclosporine together with systemic use of ciprofloxacin.

Ciprofloxacin is incompatible with alkaline solutions.

Special Instructions

Contraindications

Hypersensitivity to the components of the drug, viral and fungal eye lesions, pregnancy, breast-feeding period, children under 1 year.

With caution:

The solution in the form of eye drops is not intended for intraocular injections.
When using other ophthalmic medications, the interval between injections should be at least 15 minutes.

Side effects

Allergic reactions, itching and burning in the eye, mild pain and hyperemia of the conjunctiva, nausea, rarely – eyelid edema, photophobia, lacrimation, foreign body sensation in the eye, unpleasant taste in the mouth immediately after injection, reduced visual acuity, appearance of white crystalline precipitate in patients with corneal ulcer, keratitis, keratopathy, corneal infiltration, development of superinfection.

Overdose

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