Ciprofloxacin-ACOS, eye drops 0.3% 5 ml

Ciprofloxacin is a broad-spectrum antimicrobial drug from the group of fluoroquinolones. It inhibits bacterial enzyme DNA-gyrase, as a result DNA replication and synthesis of bacterial cell proteins are disrupted. It acts both on multiplying microorganisms and on those in a resting phase.

Pharmacodynamics

Active against Gram-negative aerobic bacteria: Enterobacteriaceae (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp, Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp.), other Gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.); some intracellular pathogens (Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium intracellulare); Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Staphylococcus hominis), to a lesser extent – Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae). Most methicillin-resistant staphylococci are resistant to ciprofloxacin.

The sensitivity of the bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate.

The following bacteria are resistant to the drug: Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Clostridium difficile, Nocardia asteroides, Ureaplasma urealyticum. The action of the drug against Treponema pallidum has not been studied sufficiently.

Pharmacokinetics

The reported C_max in blood plasma when using eye drops is less than 5 ng/ml. The average concentration is less than 2.5 ng/mL.

Indications

Infectious and Inflammatory Eye Diseases:

Active ingredient

Composition

1 ml of eye drops contains:

Active substance:

ciprofloxacin 3 mg,

Associates:

Ethylenediaminetetetraacetic acid diatriic acid salt;

mannitol;

Anhydrous or 3-water sodium acetate;

Petter acetic acid;

Benzalkonium chloride;

Injectable water.

How to take, the dosage

In mild to moderate-to-severe infection, 1-2 drops in the conjunctival sac of the affected eye (or both eyes) every 4 hours. For severe infection – 2 drops every hour. After improvement of condition the dose and frequency of instillation are reduced.

Interaction

Interaction with other drugs has not been described.

Special Instructions

Eye drops are used only topically. Do not inject subconjunctivally or directly into the anterior chamber of the eye.

Do not touch the tip of the dropper to the eye when injecting. The bottle should be closed after each use.

If conjunctival hyperemia continues or increases with prolonged use, discontinue use.

Wearing of soft contact lenses is not recommended during treatment. Before using rigid lenses – they should be removed and put on again not earlier than 15-20 min after instillation of the drug.

Patients taking the drug should be careful when driving a vehicle and engaging in other potentially dangerous activities requiring increased attention and quick psychomotor reactions.

Contraindications

Cautiousness: the drug should be used in patients with cerebral atherosclerosis, cerebral blood circulation disorder, convulsive syndrome.

Side effects

Allergic reactions, itching, burning, mild conjunctival pain and hyperemia, nausea, vomiting, rare – eyelid edema, photophobia, lacrimation, foreign body sensation in the eye, unpleasant taste in the mouth immediately after injection, decreased visual acuity, appearance of white crystalline precipitate in patients with corneal ulcer, keratitis, keratopathy, appearance of spots or corneal infiltration.

Overdose

There are no data on overdose.

Pregnancy use

Perhaps use during pregnancy and during breastfeeding if the expected effect of therapy exceeds the potential risk to the fetus or child.

Pediatric use

The drug is contraindicated in children under 1 year of age.

Similarities