Cinnarizin, tablets 25 mg 56 pcs

Selective blocker of “slow” calcium channels, reduces the entry of calcium ions into cells and decreases their content in the plasma membrane depot, reduces the tone of arteriolar smooth muscle. By directly affecting the vascular smooth muscle, it reduces their response to biogenic substances (adrenaline, noradrenaline, dopamine, angiotensin, vasopressin).

The drug is absorbed in the stomach and intestine. The maximum concentration in blood plasma after oral administration is 1-3 hours. Binding of cinnarizine with plasma proteins is 91%. It is fully metabolized in the liver (via dealkylation). The elimination half-life is 4 hours. It is excreted as metabolites: 1/3 – by kidneys and 2/3 – with feces – by intestine.

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Indications

Active ingredient

Composition

1 tablet contains:
active ingredient:
cinnarizine – 0,025 g
excipients:
potato starch – 0.0178 g
lactose (milk sugar) – 0.102 g
povidone medium molecular – 0.0030 g colloidal silica (aerosil) – 0,0007 g
magnesium stearate – 0,0015 g

How to take, the dosage

Internal, after meals.
Adults:

The maximum daily dose of the drug should not exceed 225 mg (9 tablets) a day.
For children over 5 years old – 1/2 of the dose recommended for adults, for all indications.
Duration of treatment course – from several weeks to several months. The drug should be taken continuously to achieve optimal therapeutic effect.
In case of high sensitivity to the drug treatment should be started with 1/2 dose, increasing it gradually.

Interaction

When Cinnarizine is used together with ethanol (or ethanol-containing drugs), hypotensive, nootropic and vasodilators, other drugs depressing CNS (tricyclic antidepressants, sleeping pills, sedatives) their action is increased.

Special Instructions

Contraindications

Hypersensitivity, pregnancy, lactation.

Lactose intolerance,

Lactase deficiency,

glucose-galactose malabsorption syndrome.

With caution

Parkinson’s disease.

Side effects

Nervous system disorders: drowsiness, fatigue, headache, extrapyramidal disorders (limb tremor and increased muscle tone, hypokinesia), depression. Digestive system: dry mouth, epigastric pain, dyspepsia, cholestatic jaundice.

Overdose

Pregnancy use

Similarities