Cetrin, 10 mg 20 pcs.

Pharmacodynamics

Competitive histamine antagonist, hydroxyzine metabolite, blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects. It affects the early stage of allergic reactions, limits the release of inflammatory mediators at the “late” stage of the allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. It reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm.

It eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). It reduces histamine-induced bronchoconstriction in mild bronchial asthma.
It has almost no anticholinergic and antiserotonin action.

In therapeutic doses the sedative effect is practically absent. The beginning of the effect after a single dose of 10 mg of cetirizine is 20 minutes and lasts for more than 24 hours. During the course of treatment tolerance to antihistamine action of cetirizine does not develop. After discontinuation of treatment the effect lasts up to 3 days.

Pharmacokinetics

Indications

Allergies, Sneezing, Pollinosis, Allergic rhinitis, Neurodermitis, Runny nose (rhinitis), Allergic conjunctivitis, Skin itching, Urticaria, Dermatosis, Increased lacrimation

• Seasonal and year-round allergic rhinitis;

• allergic conjunctivitis;
• pollenosis (hay fever);
• tetritis, including chronic idiopathic urticaria

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• itching allergic dermatoses (atopic dermatitis, neurodermitis);
• angioedema (Quincke’s edema).

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Active ingredient

Cetirizine

Composition

Each film-coated tablet contains:

Active ingredient:

Cetirizine dihydrochloride 10 mg

Associates:

Lactose

Cornstarch

Povidone (K-30)

Magnesium stearate

Film coating:

Hypromellose

Macrogol 6000

Titanium dioxide

Talc

Sorbic acid

Polysorbate 80

Dimethicone

How to take, the dosage

Orally, regardless of meals, without chewing, wash down with 200 ml of water.

Adults: 10 mg (1 tablet) once a day or 5 mg (1/2 tablet) two times a day.

Children over 6 years of age: 5 mg (1/2 tablet) two times a day or 10 mg (1 tablet) once a day.

In patients with decreased renal function (creatinine clearance 30-49 ml/min) 5 mg/day (1/2 tablet) is prescribed, in severe chronic renal failure (creatinine clearance 10-30 ml/min) – 5 mg/day (1/2 tablet) every other day.

Interaction

Pharmacokinetic interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam and glipizide was not found.

The co-administration with theophylline (400 mg/day) results in decreased total clearance of cetirizine (the kinetics of theophylline is not altered).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special Instructions

The ability to react quickly may be impaired if the dose of 10 mg/day is exceeded.

In recommended doses it does not increase the effect of ethanol (at its concentration not more than 0.8 g/l), however, it is recommended to refrain from its use during treatment.

For children (from 2 years of age) Cetrin® is used in the form of syrup.

When using this medicine, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Synopsis

Round biconvex film-coated tablets, white or almost white, with a rib on one side.

On the cross section the core is white to almost white.

Contraindications

• Hypersensitivity (including to hydroxyzine);

• Pregnancy, breastfeeding period;

• children under 6 years of age (for this dosage form).

Cautions:

Chronic renal insufficiency (moderate and severe – dosage regimen adjustment required), advanced age (decreased glomerular filtration possible).
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Side effects

Cetrin® is usually well tolerated.

Overdose

Symptoms (occurs with a single dose of 50 mg) – dry mouth, drowsiness, delayed urination, constipation, restlessness, increased irritability.

Treatment:Gastric lavage, prescription of symptomatic drugs.

There is no specific antidote.

Hemodialysis is ineffective.

Pregnancy use

Pregnancy

An analysis of prospective data on the outcomes of pregnancy revealed no cases of malformations, fetal and neonatal toxicity with a clear causal relationship.

Studies on animals have not revealed any direct or indirect adverse effects of cetirizine on the developing fetus (including in the postnatal period), during pregnancy and childbirth.

Controlled clinical studies on the safety of the drug during pregnancy have not been conducted, so cetirizine should not be used during pregnancy.

Breastfeeding

Cetirizine is excreted with breast milk at concentrations representing 25% to 90% of the drug’s plasma concentration depending on the time of administration. During breastfeeding, the drug is used after consultation with a physician if the anticipated benefit to the mother exceeds the potential risk to the child.

Fertility

The available data on the effect on human fertility are limited, but no adverse effects on fertility have been identified.

Similarities

Zyrtec, Cetrine, Zodac, Cetirizine, Cetirizine-Teva, Cetirizine drops, Solonex