Cerekard 50 mg/ml 2 ml, 10 pcs.

The drug is from the group of 3-oxypyridines. It is an inhibitor of free radical processes – a membranoprotector, which also has antihypoxic, stress protective, nootropic, antiepileptic and anxiolytic effects. The mechanism of action is due to the antioxidant and membrane-protective properties. It inhibits lipid peroxidation, increases superoxidase activity, increases lipid-protein ratio, improves the structure and function of cell membrane.

. It modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, gamma-aminobutyric acid, acetylcholine), which promotes their binding to ligands, preserving the structural and functional organization of biomembranes, transport of neurotransmitters and improving synaptic transmission.

Enhances dopamine concentration in the brain. Increases compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle in hypoxia with an increase in ATP and creatine phosphate, activates the energy-synthesizing function of mitochondria. Increases the body’s resistance to various damaging factors in pathological conditions.

It improves metabolism and blood supply of the brain, microcirculation and blood rheology, reduces platelet aggregation. It stabilizes blood cell membranes (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a hypolipidemic effect, reduces the content of total cholesterol and low-density lipoproteins.

It improves functional condition of ischemic myocardium in myocardial infarction, the contractile function of heart, and also reduces manifestations of systolic and diastolic dysfunction of the left ventricle.

In conditions of critical reduction of coronary blood flow, it promotes the preservation of structural and functional organization of cardiomyocyte membranes, stimulates the activity of membrane enzymes: phosphodiesterase, adenylate cyclase, acetylcholinesterase. It supports activation of aerobic glycolysis developing in acute ischemia and promotes under hypoxia restoration of mitochondrial redox processes, increases ATP and creatine phosphate synthesis. Provides integrity of morphological structures and physiological functions of ischemic myocardium.

It improves clinical course of myocardial infarction, increases the effectiveness of therapy, accelerates the restoration of functional activity of myocardium of the left ventricle, reduces the incidence of arrhythmias and intracardiac conduction disorders. It normalizes metabolic processes in the ischemic myocardium, reduces the zone of necrosis, restores and/or improves myocardial electrical activity and contractility, as well as increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro preparations, improves blood rheological properties, reduces the consequences of reperfusion syndrome in acute coronary failure.

Indications

The drug is used as part of the complex therapy for:

Active ingredient

Composition

Ethylmethylhydroxypyridine succinate 50 mg/ml.

How to take, the dosage

The drug is administered intramuscularly or intravenously by jetting (for 5-7 minutes) or dropwise (at the rate of 60 drops per minute).
When administering by infusion the drug is pre-diluted in 200 ml of 0.9% sodium chloride solution. Initial dose of the drug is 50-100 mg 1-3 times a day with gradual increase to obtain therapeutic effect. The maximum daily dose is 800 mg.

In case of acute impairment of cerebral circulation the drug is administered intravenously by drip 200-300 mg 1 time daily during the first 2-4 days and then intramuscularly 100 mg 3 times a day.

In case of dyscirculatory encephalopathy (decompensation phase) it is administered intravenously by shot or dropwise in 100 mg 2-3 times daily during 14 days and then intramuscularly in 100 mg dose for 14 days. For course prophylaxis of discirculatory encephalopathy intramuscularly 100 mg 2 times daily during 10-14 days.

Vegetovascular dystonia. neurotic and neurosis-like conditions: the drug is administered intramuscularly 50-400 mg per day for 14 days.

In case of withdrawal alcohol syndrome the drug is administered intramuscularly by 100-200 mg 2-3 times a day or intravenously by drip 100-200 mg 1-2 times a day for 5-7 days.

In acute intoxication with antipsychotic drugs the drug is administered intravenously 50-300 mg per day for 7-14 days.
Mild cognitive impairment: intramuscularly 100-300 mg per day for 14-30 days.

Acute myocardial infarction: in the first 5 days the preparation is carried intravenously by infusion for 30-90 minutes (in 100-150 ml of 0.9% sodium chloride solution or 5% dextrose solution) or intravenously by shot for at least 5 minutes. During the next 9 days the drug is administered intramuscularly 3 times a day (every 8 hours). The daily dose is 6-9 mg/kg/day, the single dose is 2-3 mg/kg. The maximum daily dose should not exceed 800 mg, a single dose is 250 mg.

Interaction

It enhances the effect of benzodiazepine anxiolytics, antiepileptic (carbamazepine), anti-Parkinsonian (levodopa) drugs, nitrates.

Limits the toxic effects of ethanol.

Special Instructions

During treatment, caution should be exercised when driving vehicles and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

With caution
Allergic diseases in the anamnesis.

Side effects

Nausea, dry mouth, diarrhea, drowsiness, allergic reactions.

In parenteral administration (especially intravenous jetting): dryness, “metallic” taste in the mouth, sensations of “spreading heat” throughout the body, unpleasant odor, throat and chest discomfort, feeling of lack of air (usually associated with excessive speed of administration and are short-term); with long-term use – nausea, flatulence; sleep disorders (drowsiness or trouble falling asleep).

Overdose

Symptoms: sleep disturbances (insomnia, in some cases – somnolence); when injected intravenously – slight and transient (up to 1.5-2 hours) increase in BP.

Treatment: usually not required – symptoms disappear on their own within 24 hours. In severe cases with insomnia – nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg. In excessive rise in BP – hypotensive drugs under control of BP.

Similarities