Candibiotic, ear drops 5 ml

Pharmacotherapeutic group – corticosteroids in combination with antimicrobials.

The ATX code is S02CA.

Pharmacological action

Antimicrobial topical, antibacterial, anti-inflammatory topical, topical anesthetic.

Clotrimazole (imidazole derivative) is a broad-spectrum antifungal agent for topical use. The antifungal effect of clotrimazole is associated with disruption of ergosterol synthesis, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

Chloramphenicol is a broad spectrum bacteriostatic antibiotic. It disrupts protein synthesis in the microbial cell. It is active against Gram-positive and Gram-negative bacteria.

Beclomethasone dipropionate is a glucocorticosteroid. It has anti-inflammatory and anti-allergic effects.

Lidocaine is a local anesthetic. Causes reversible blockade of impulse conduction through nerve fibers by blocking the passage of sodium ions through the membrane.

Pharmacokinetics

Pharmacokinetic studies of the drug have not been conducted.

Indications

Allergic and inflammatory diseases of the ear, including:

acute and diffuse external otitis media;
acute otitis media;
chronic otitis in the acute stage;
condition after ear surgery.

Pharmacological effect

Pharmacotherapeutic group – corticosteroids in combination with antimicrobial drugs.

ATX code – S02CA.

Pharmacological action

Local antimicrobial, antibacterial, local anti-inflammatory, local anesthetic.

Clotrimazole (imidazole derivative) is a broad-spectrum antifungal agent for topical use. The antifungal effect of clotrimazole is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

Chloramphenicol is a broad-spectrum bacteriostatic antibiotic. Disturbs the process of protein synthesis in the microbial cell. Active against gram-positive and gram-negative bacteria.

Beclomethasone dipropionate is a glucocorticosteroid. Has anti-inflammatory and anti-allergic effects.

Lidocaine is a local anesthetic. Causes a reversible blockade of impulse conduction

along nerve fibers by blocking the passage of sodium ions through the membrane.

Pharmacokinetics

Pharmacokinetic studies of the drug have not been conducted.

Special instructions

Active ingredient

Beclomethasone, Clotrimazole, Lidocaine, Chloramphenicol

Composition

Each milliliter contains:

Active ingredients: chloramphenicol – 50.0 mg, beclomethasone dipropionate (anhydrous) – 0.25 mg, clotrimazole – 10.0 mg, lidocaine hydrochloride monohydrate, calculated as lidocaine hydrochloride – 20.0 mg.

Excipients: glycerol, propylene glycol

Pregnancy

The question of the advisability of prescribing the drug during pregnancy should be decided individually after consulting a doctor. Prescription of the drug is possible if the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity to the components of the drug.
Children’s age (up to 6 years).
Violation of the integrity of the eardrum.

Side Effects

Rarely, there may be burning and itching at the site of application, and allergic reactions are also possible.

Interaction

No data available.

Overdose

No data available.

Storage conditions

Store in a place protected from light at a temperature of 2 to 8 ºC. Do not freeze.
After opening the package, store at a temperature not exceeding 30 ºC for no more than 1 month.
Keep out of the reach of children.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Glenmark Pharmaceuticals Ltd, India