Calcemin Advance, 30 pcs.

Calcemin Advance is a product with an enhanced formula that contains vitamin D3 and minerals for the prevention of bone fragility and the comprehensive treatment of osteoporosis.

With age, calcium is washed out of bones and they become fragile.

Unlike other calcium preparations (3), Calcemin Advance contains special minerals (magnesium, zinc, manganese, copper, boron) for formation of collagen mesh, which holds calcium in bone tissue, preventing its washout (4).

Calcemin Advance is used:

– for the prevention and comprehensive treatment of osteoporosis;

– to improve healing of fractures;

– to compensate for calcium and trace element deficiency

Calcemin Advance – to keep bones strong!

Indications

Prevention and complex treatment of osteoporosis of different genesis:

– in women during menopause (natural and surgical);

– in persons taking long-term GCS and immunosuppressants.

Therapy of musculoskeletal disorders (to improve the consolidation of traumatic fractures)

To replenish calcium and trace element deficiencies in adolescents.

Composition

Active substances:

calcium (calcium citrate and calcium carbonate) 500 mg,

colocalciferol (vitamin D3) 200 IU,

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magnesium 40 mg,

zinc 7.5 mg,

copper 1 mg,

Manganese 1.8 mg,

Boron 250 µg.

Auxiliary substances:

Maltodextrin 25 mg,

Microcrystalline cellulose 49, 05 mg,

Sodium croscarmellose 38 mg,

stearic acid 16, 3 mg,

soy polysaccharide 15 mg,

sodium lauryl sulfate 5 mg.

Shell:

Hypromellose 26, 328 mg,

Titanium dioxide 12, 643 mg,

magnesium silicate 5 mg,

triacetin 5, 689 mg,

mineral oil 2, 845 mg,

dye red #40 (dye red charming) 0, 316,

dye yellow #6 (sunset yellow) 0, 079 mg,

dye blue #1 0, 04 mg.

How to take, the dosage

Take orally, with meals.

The complex therapy of osteoporosis – 1 tablet 2 times a day.

Prevention of osteoporosis – 1 tablet a day.

When taking the preparation for prophylaxis and in complex therapy of osteoporosis the duration of treatment is determined by the doctor individually. Average course duration for prophylaxis is 2 months and for treatment of osteoporosis – 3 months.

Therapy of musculoskeletal system disorders: to improve the consolidation of traumatic fractures – 1 tablet a day, the duration of treatment is 4-6 weeks.

To replenish calcium and trace elements deficiency in adolescents from 12 years of age – 1 tablet a day. The average duration of treatment is 4-6 weeks.

Interaction

In concomitant use of Calcemin with vitamin A toxicity of vitamin D3 is reduced. Phenytoin, barbiturates, GCS reduce the effectiveness of vitamin D3. Laxatives reduce absorption of vitamin D3. GCS, hormonal contraceptives for systemic use, levothyroxine impair absorption of calcium ions.

In concomitant use of tetracyclines interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (impaired absorption) – at least 2 hours. Calcemin drug co-administration with cardiac glycosides increases their toxicity (ECG and clinical condition monitoring is necessary), with thiazide diuretics – the risk of hypercalcaemia increases, with furosemide and other loop diuretics – renal calcium excretion increases.

Calcemin should not be used simultaneously with calcium channel blockers. It is not recommended to use in combination with antacids containing aluminum due to decrease of their effectiveness.

Special Instructions

Contraindications

Individual hypersensitivity to the drug components, hypervitaminosis of vitamin D, hypercalcemia and hypercalciuria, severe renal failure, urolithiasis, active tuberculosis, sarcoidosis, children (under 12 years), allergic reactions to peanut oil and soy, since the drug contains soy polysaccharide.

With caution:

Pregnancy and lactation period, renal failure.

Overdose

Vitamin D hypervitaminosis, hypercalcemia and hypercalciuria.

Symptoms: decreased appetite, thirst, polyuria, dizziness, fainting, constipation, nausea and vomiting, muscle weakness, headache, coma, increased fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis, in severe cases – cardiac arrhythmias.

In long-term use in doses over 2500 mg of calcium – kidney damage, soft tissue calcinosis.

If the first signs of overdose are detected, reduce the dose or stop using the drug and seek medical attention.

In case of hypercalciuria greater than 7.5 mmol/d (300 mg/d), the dose should be reduced or the drug stopped.

Treatment: rehydration, use of loop diuretics (e.g., furosemide), glucocorticosteroids, calcitonin, bisphosphonates, in severe cases hemodialysis.

In case of accidental overdose, vomiting and gastric lavage should be induced. Therapy is symptomatic.

The dose should be reduced or the drug should be discontinued. In case of accidental overdose, vomiting and gastric lavage should be induced. Therapy is symptomatic.

Pregnancy use

During pregnancy and breast-feeding the drug administration should be coordinated with the doctor.

The fixed dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3; hypergallcemia caused by overdose during pregnancy can cause defects in the mental and physical development of the fetus.

In breastfeeding women it should be taken into account that colecalciferol and its metabolites penetrate into the breast milk, so the intake of calcium and vitamin D3 must be considered.