Caffetine Light, tablets 12 pcs

Caffetine^® sk is a combined analgesic drug.

Paracetamol and propiphenazone have analgesic and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis. The presence of caffeine in combined analgesics promotes increased absorption of components.

The combination of drugs provides satisfactory analgesic effects, and the use of small amounts of the components reduces the risk of side effects.

Pharmacokinetics

The pharmacokinetic characteristics of combination drugs are not significant because the drugs are not designed to treat chronic conditions and therefore are used as needed or in short-term courses.

All active components of the drug Caffetine^® sk have a similar pharmacokinetic profile, which justifies the rationality of the analgesic combination. They are absorbed very rapidly and their maximum plasma concentrations are reached 30-60 min after administration.

They are metabolized in the liver and excreted in the urine.

During biotransformation of paracetamol, a small amount of the toxic metabolite N-acetil-p-benzo-quinoneimine is created, which can manifest in the liver.

Indications

Pain syndrome of moderate severity of various origins: headache and toothache, migraine, neuralgia, myalgia, post-traumatic pain, arthralgia, algodismenorrhea, fever due to influenza infections.

Pharmacological effect

Caffetin® sk is a combined drug with analgesic action.

Paracetamol and propyphenazone have analgesic and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis. The presence of caffeine in combined analgesics increases the absorption of the components.

The combination of the drug ensures a satisfactory analgesic effect, and the use of small quantities of the components reduces the risk of side effects.

Pharmacokinetics

The pharmacokinetic characteristics of combination drugs are not significant, since the drugs are not intended for the treatment of chronic diseases and are therefore used as needed or in short courses.

All active components of the drug Caffetin® sk have a similar pharmacokinetic profile, which justifies the rationality of the analgesic combination. They are absorbed very quickly and their maximum plasma concentrations are reached 30-60 minutes after administration.

Metabolized in the liver and excreted in the urine.

During the biotransformation of paracetamol, a small amount of the toxic metabolite N-acetil-p-benzo-quinoneimine is created, which can cause liver damage.

Special instructions

With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary. During treatment, you should avoid drinking alcoholic beverages (increased risk of gastrointestinal bleeding).

Excessive consumption of caffeine-containing products (coffee, tea) while taking the drug may cause overdose symptoms. Taking the drug may make it difficult to establish a diagnosis for acute abdominal pain syndrome.

Patients suffering from bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions.

With caution. Elderly, childhood, glaucoma.

Influence on the ability to drive vehicles and machinery. Caffetin® sk does not affect the ability to drive vehicles and machines.

Active ingredient

Caffeine, Paracetamol, Propyphenazone

Composition

1 tab.:
paracetamol 250 mg;
propyphenazone 210 mg;
caffeine 50 mg.
Excipients:
magnesium stearate 13.5 mg,
sodium lauryl sulfate 1.5 mg,
sodium starch glycolate 14.5 mg,
colloidal silicon dioxide 2.5 mg,
povidone 12.5 mg,
calcium dihydrogen phosphate 21.1 mg,
microcrystalline cellulose 28.5 mg,
croscarmellose sodium 9.6 mg,
glyceryl dibehenate 6.3 mg.

Pregnancy

Caffetin® is contraindicated for use during pregnancy and breastfeeding.

Contraindications

Increased individual sensitivity to the components of the drug;
liver and/or kidney failure;
glucose-6-phosphate dehydrogenase deficiency;
leukopenia;
hematopoietic disorder;
increased excitability;
insomnia;
angina pectoris against the background of coronary sclerosis;
pregnancy and lactation;
children’s age (up to 7 years).

Side Effects

Leukopenia, agranulocytosis, nausea, gastralgia, vomiting, increased activity of liver transaminases, increased excitability (especially in children), allergic reactions (skin rash, Quincke’s edema, itching, urticaria).

Interaction

The combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drinks should be avoided (the risk of hepatotoxic effect increases).

Under the influence of paracetamol, the elimination time of chloramphenicol increases 5 times. Metoclopramide accelerates the absorption of paracetamol. When taken repeatedly, paracetamol may enhance the effect of anticoagulants (dicoumarin derivatives).

Caffeine accelerates the absorption of ergotamine.

Overdose

Symptoms: nausea, vomiting, ringing in the ears, stomach pain, sweating, pale skin, tachycardia. If you suspect poisoning, you should immediately seek medical help.

Assistance: the victim should undergo gastric lavage and be prescribed adsorbents (activated carbon).

Storage conditions

Store at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life

3 years.

Manufacturer

Alkaloid AD Skopje, Republic of North Macedonia