Caffetine Light, tablets 12 pcs

Caffetine^® sk is a combined analgesic drug.

Paracetamol and propiphenazone have analgesic and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis. The presence of caffeine in combined analgesics promotes increased absorption of components.

The combination of drugs provides satisfactory analgesic effects, and the use of small amounts of the components reduces the risk of side effects.

Pharmacokinetics

The pharmacokinetic characteristics of combination drugs are not significant because the drugs are not designed to treat chronic conditions and therefore are used as needed or in short-term courses.

All active components of the drug Caffetine^® sk have a similar pharmacokinetic profile, which justifies the rationality of the analgesic combination. They are absorbed very rapidly and their maximum plasma concentrations are reached 30-60 min after administration.

They are metabolized in the liver and excreted in the urine.

During biotransformation of paracetamol, a small amount of the toxic metabolite N-acetil-p-benzo-quinoneimine is created, which can manifest in the liver.

Indications

Pain syndrome of moderate severity of different genesis: headache, toothache, migraine, neuralgia, myalgia, post-traumatic pain, arthralgia, algodysmenorrhea, fever with influenza infections.

Active ingredient

Caffeine, Paracetamol, Propiphenazone

Composition

1 tablet:

• paracetamol 250 mg;
• propifenazone 210 mg;
• caffeine 50 mg.

Excipients:

• magnesium stearate 13.5 mg,
• sodium lauryl sulfate 1.5 mg,
• sodium starch glycolate 14.5 mg,
• silica colloidal dioxide 2.5 mg,
• povidone 12.5 mg,
• calcium dihydrophosphate 21.1 mg,
• cellulose microcrystalline 28.5 mg,
• croscarmellose sodium 9.6 mg,
• glyceryl dibegenate 6.3 mg.

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How to take, the dosage

In adults, 1 tablet 3-4 times a day. In severe pain it is recommended to take 2 tablets at once. The maximum daily dose is 6 tablets.

Children over 7 years of age are prescribed 1/4-1/2 tablets, 1-4 times a day.

The duration of the drug is not more than 5 days. The daily dose of the drug or the duration of treatment may only be increased after consulting a physician.

Interaction

Combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcoholic beverages should be avoided (increased risk of hepatotoxic effect).

The elimination time of chloramphenicol increases by 5 times under the influence of paracetamol. Metoclopramide accelerates absorption of paracetamol. When repeated administration of paracetamol may increase the effect of anticoagulants (dicumarin derivatives).

Caffeine accelerates absorption of ergotamine.

Special Instructions

Long-term use of the drug requires monitoring of peripheral blood and functional status of the liver. During treatment, alcohol-containing beverages should be avoided (increased risk of gastrointestinal bleeding).

The excessive use of caffeine-containing products (coffee, tea) while taking the drug may cause symptoms of overdose. Taking the drug may make it difficult to establish a diagnosis in acute abdominal pain syndrome.

In patients with bronchial asthma, pollinosis, there is an increased risk of hypersensitivity reactions.

With caution. Elderly, childhood, glaucoma.

Impact on the ability to drive vehicles, machinery. Caffetine^® sk has no effect on the ability to drive vehicles and machines.

Contraindications

• Excessive individual sensitivity to drug components;
• Glucose-6-phosphate dehydrogenase deficiency;
• leukopenia;
disorder of hematopoiesis;
• excitability;
• insomnia;
• angina pectoris with coronary artery disease;
• pregnancy and lactation;
• children (under 7 years).

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Side effects

Leukopenia, agranulocytosis, nausea, gastralgia, vomiting, increased activity of liver transaminases, increased excitability (especially in children), allergic reactions (skin rash, Quincke’s edema, itching, urticaria).

Overdose

Symptoms: nausea, vomiting, tinnitus, stomach pain, sweating, pale skin, tachycardia. If poisoning is suspected, seek medical attention immediately.

Care: the victim should be given gastric lavage and administration of adsorbents (activated charcoal).

Pregnancy use

Caffetine^® is contraindicated in pregnancy and during lactation.

Similarities

Novalgin, Safiston