Bromhexin, 4 mg/5 ml 60 ml

Pharmacotherapeutic group: expectorant mucolytic agent

ATX code: [R05CB02]

Pharmacological properties

Pharmacodynamics.

Bromhexin Nicomed has mucolytic (secretolytic), expectorant and mild anti-cough.
Mucolytic effect is associated with depolymerization of mucoprotein and mucopolysaccharide fibers and an increase in the serous component of bronchial secretion.

Pharmacokinetics

In oral administration, bromhexine is almost completely (99%) absorbed in the gastrointestinal tract within 30 minutes. Bioavailability depends on the individual characteristics of the body, the activity of renal enzymes during the primary passage of the active substance through the liver and is about 20%. Bromhexin in plasma binds to proteins, penetrates through the blood-brain and placental barriers.

In the liver bromhexine undergoes demethylation and oxidation, part of the resulting metabolites (ambroxol) retains activity. Limit half-life is 15 hours due to slow reverse diffusion from tissues. Maximum concentration in blood is reached about 1 hour after intake. It is excreted by the kidneys. Excretion of bromhexin metabolites is impaired in chronic renal failure. Bromhexin may cumulate with repeated use.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

For diabetics: 5 ml of the solution contains 1.5 g of sorbitol, which corresponds to 0.12 bread units.
The preparation contains alcohol in concentration of 3%, which is 0.6 g for adults (20 ml) and 0.075 g for children (2.5 ml).

Impact on ability to drive vehicles and equipment

The administration of the recommended therapeutic doses (20 ml 3 times a day) does not affect the speed of psychomotor reactions of the patient.

Significant exceeding of the recommended doses of a product containing 3% alcohol may affect the speed of psychomotor reactions and be dangerous when driving or operating machinery.

Contraindications

– Hypersensitivity to the components of the drug;
– pregnancy and lactation;
– peptic ulcer (acute stage);
– children under 3 years of age.

With caution when using in patients with a history of gastric bleeding, bronchial diseases accompanied by excessive secretion, with a history of episodes of hemoptysis, renal and/or hepatic insufficiency.

The presence of alcohol in the drug (3%) may have adverse effects on children, pregnant women, people with brain diseases, in case of craniocerebral trauma and alcoholism.

Side effects

Overdose

Similarities