Braunodin B. Brown, 10% ointment 20 g

The antiseptic agent is a complex of iodine and povidone, effective at pH from 2 to 7.

The bactericidal effect is due to free active iodine that is released from the povidone-iodine complex.

In comparison with alcohol-containing iodine solutions, aqueous solution of povidone-iodine has significantly less irritating effect.

Free iodine as a strong oxidizing agent reacts on molecular level with insoluble fatty acids and rarely oxidized SH- and OH-groups of amino acids within enzymes and main structural components of Gram-positive and Gram-negative bacteria, mycobacteria, fungi, especially Candida type, various viruses and some protozoa.

However, the complete inactivation of some viruses and bacterial spores requires a fairly long period of exposure to the drug. There are no known cases of the development of resistance in microorganisms with prolonged use of povidone iodine.

Indications

Post-traumatic and postoperative wounds of various locations, burns, trophic ulcers, bedsores.

Skin infections of various etiologies, including infectious dermatitis and eczema.

Damage to the skin of various origins (maceration, abrasions, bruises).

Pharmacological effect

An antiseptic, which is a complex of iodine and povidone, effective at pH from 2 to 7.

The bactericidal effect is due to free active iodine, which is released from the povidone-iodine complex.

Compared to alcohol-containing iodine solutions, an aqueous solution of povidone-iodine has a significantly less irritating effect.

Free iodine, as a strong oxidizing agent, reacts at the molecular level with insoluble fatty acids and practically non-oxidizable SH- and OH-groups of amino acids in enzymes and the main structural components of bacteria, both gram-positive and gram-negative, mycobacteria, fungi, especially the genus Candida (Candida), various viruses and some protozoa.

However, for complete inactivation of some viruses and bacterial spores, a sufficiently long period of exposure to the drug is required. There are no known cases of the development of resistance in microorganisms with long-term use of povidone-iodine.

Active ingredient

Povidone-Iodine

Composition

Active ingredient:

povidone-iodine (containing active iodine 10%) 10.0 g.

Contraindications

Hypersensitivity to the components of the drug. Thyroid dysfunction (thyrotoxicosis). Thyroid adenoma. Dühring’s dermatitis herpetiformis.

Simultaneous use of radioactive iodine. Premature babies, newborns and children up to 6 months.

Side Effects

Hypersensitivity reactions to the drug are possible: delayed allergic reactions (itching, redness of the skin, blisters) or immediate allergic reactions (anaphylactoid reactions).

Long-term use of the drug (more than 7-10 days) and application to large surfaces of the skin, extensive wounds due to absorption can cause symptoms of iodism (“metallic” taste in the mouth, increased salivation and lacrimation, swelling of the mucous membranes) and systemic reactions (metabolic acidosis, hyponatremia, impaired renal and thyroid function), if they occur, you should stop using the drug and consult a doctor.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, silver salts, bismuth, taurolidine and hydrogen peroxide. In the presence of blood and pus, the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may decrease.

In this case, it is recommended to increase the multiplicity/frequency of its use. The simultaneous use of povidone-iodine and topical preparations containing enzymes may promote oxidation and suppress their enzymatic activity.

Povidone-iodine has a synergistic effect with lithium preparations, as a result of which, with their long-term combined use, reversible depression of thyroid function is possible. Therefore, patients chronically taking lithium should avoid prolonged application of povidone-iodine to large surfaces.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, testing of thyroid function, etc. In this case, examination of the thyroid gland should be carried out no earlier than 1-2 weeks after the end of treatment with povidone-iodine.

Overdose

With intense iodine absorption over a long period, the following symptoms may be noted: tachycardia, restlessness, tremors and headache.

In this case, you should immediately stop using the drug and consult a doctor.

Storage conditions

Store in a place protected from light, out of reach of children, at a temperature of 2 to 25 C.

Manufacturer

B. Braun Melsungen AG, Switzerland