Braunodin B. Brown, 10% ointment 100 g

Povidone iodine is an antiseptic agent that is a complex of iodine and povidone effective at pH 2 to 7.

The bactericidal effect is due to free active iodine, which in the ointment is released from the povidone-iodine complex. As a strong oxidizing agent, free iodine reacts on the molecular level with insoluble fatty acids and almost non-oxidizing SH- and OH-groups of amino acids, which are part of enzymes and main structural components of bacteria, both Gram-positive and Gram-negative mycobacteria, fungi, especially Candida, various viruses and some protozoa. However, for the complete inactivation of some viruses and bacterial spores a fairly long period of exposure to the drug is required.

There are no known cases of development of resistance in microorganisms after long-term use of povidone iodine.

Pharmacokinetics:

Indications

Post-traumatic and postoperative wounds of various locations, burns, trophic ulcers, bedsores.

Skin infections of various etiologies, including infectious dermatitis and eczema.

Damage to the skin of various origins (maceration, abrasions, bruises).

Pharmacological effect

Povidone-iodine is an antiseptic that is a complex of iodine and povidone, effective at pH from 2 to 7.

The bactericidal effect is due to free active iodine, which is released from the povidone-iodine complex in the ointment. Free iodine, as a strong oxidizing agent, reacts at the molecular level with insoluble fatty acids and practically non-oxidizable SH- and OH-groups of amino acids in enzymes and the main structural components of bacteria, both gram-positive and gram-negative mycobacteria, fungi, especially the genus Candida, various viruses and some protozoa. However, for complete inactivation of some viruses and bacterial spores, a sufficiently long period of exposure to the drug is required.

There are no known cases of the development of resistance in microorganisms with long-term use of povidone-iodine.

Pharmacokinetics:

Special instructions

Avoid getting the drug into your eyes.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, testing of thyroid function, etc. In this case, examination of the thyroid gland should be carried out no earlier than 1-2 weeks after the end of treatment with povidone-iodine.

In the presence of blood, the bactericidal effect of povidone-iodine may be reduced.

In case of dysfunction of the thyroid gland, the use of the drug is possible only under the supervision of a physician. Use in newborns is possible only if necessary after testing the function of the thyroid gland.

Caution should be exercised when using the drug regularly in patients with chronic renal failure.

When using the drug, skin and clothing may be stained; The preparation is easily washed off and washed with water.

Please read these instructions carefully before you start using the drug as it contains important information for you.

Save the instructions as you may need them again.
If you have any questions, consult your doctor.
The medicine you are being treated with is intended for you personally and should not be shared with others as it may cause harm to them even if they have the same symptoms as you.

Impact on the ability to drive vehicles. Wed and fur.:

The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Povidone-Iodine

Composition

100 g of ointment contains:

active ingredient:

povidone-iodine (containing active iodine 10%) – 10 g;

auxiliary components:

macrogol-400,

sodium bicarbonate,

macrogol-4000,

purified water.

Contraindications

Hypersensitivity to the components of the drug.

Thyroid dysfunction (thyrotoxicosis).

Thyroid adenoma.

Dühring’s dermatitis herpetiformis.

Simultaneous use of radioactive iodine.

Premature babies, newborns and children up to 6 months.

With caution

Chronic renal failure.

Side Effects

Hypersensitivity reactions to the drug are possible: delayed allergic reactions (itching, redness of the skin, blisters) or immediate allergic reactions (anaphylactoid reactions).

Long-term use of the drug (more than 7-10 days) and application to large surfaces of the skin, extensive wounds due to absorption can cause symptoms of iodism (“metallic” taste in the mouth, increased salivation and lacrimation, swelling of the mucous membranes) and systemic reactions (metabolic acidosis, hyponatremia, impaired renal and thyroid function), if they occur, you should stop using the drug and consult a doctor.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, silver salts, bismuth, taurolidine and hydrogen peroxide.

In the presence of blood and pus, the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may decrease. In this case, it is recommended to increase the multiplicity/frequency of its use.

The simultaneous use of povidone-iodine and topical preparations containing enzymes may promote oxidation and suppress their enzymatic activity.

Povidone-iodine has a synergistic effect with lithium preparations, as a result of which, with their long-term combined use, reversible depression of thyroid function is possible. Therefore, patients chronically taking lithium should avoid prolonged application of povidone-iodine to large surfaces.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, testing of thyroid function, etc. In this case, examination of the thyroid gland should be carried out no earlier than 1-2 weeks after the end of treatment with povidone-iodine.

Overdose

With intense iodine absorption over a long period, the following symptoms may be noted: tachycardia, restlessness, tremors and headache.

In this case, you should immediately stop using the drug and consult a doctor.

Storage conditions

Store at temperatures between 2 °C and 25 °C, protected from light.

Keep out of the reach of children.

Manufacturer

B. Braun Melsungen AG, Switzerland