Belosalik lotion, spray 50 ml

The drug for external application. Belosalik® lotion has anti-inflammatory, antipruritic, antiedematous, anti-allergic, antiproliferative, immunosuppressive, keratolytic, antimicrobial, antifungal effects.

Betamethasone dipropionate is a synthetic GKS that has anti-inflammatory, anti-allergic, antipruritic and vasoconstrictive effects.

When applied to the skin surface it narrows vessels, reduces itching, decreases release of inflammatory mediators (from eosinophils and mast cells), interleukins 1 and 2 and gamma-interferon (from lymphocytes and macrophages), inhibits activity of hyaluronidase and decreases vascular wall permeability.

It interacts with specific receptors in cell cytoplasm, stimulating synthesis of mRNA, inducing formation of proteins including lipocortin, mediating cellular effects. Lipocortin inhibits phospholipase A2, blocks the release of arachidonic acid and biosynthesis of endoperoxides, prostaglandins, leukotrienes (contributing to inflammation, allergy and other pathological processes).

Salicylic acid through its keratolytic action cleanses lesion areas of scales, promotes penetration of betamethasone into the skin, maintains an acidic skin environment, preventing the development of bacterial and fungal infection.

Indications

Subacute and chronic dermatoses, sensitive to GCS therapy, and accompanied by hyperkeratosis and peeling:

Psoriasis.
Seborrhea.
Seborrheic dermatitis (scalp).
Lichen asbestos.
Neurodermatitis.
Lichen planus localized to the scalp.
Eczema.
Skin dyshidrosis.
Ichthyosis.

Pharmacological effect

Preparation for external use. Belosalik® lotion has anti-inflammatory, antipruritic, decongestant, antiallergic, antiproliferative, immunosuppressive, keratolytic, antimicrobial, antifungal effects.

Betamethasone dipropionate is a synthetic corticosteroid that has anti-inflammatory, antiallergic, antipruritic and vasoconstrictor effects.

When applied to the surface of the skin, it constricts blood vessels, relieves itching, reduces the release of inflammatory mediators (from eosinophils and mast cells), interleukins 1 and 2, interferon gamma (from lymphocytes and macrophages), inhibits the activity of hyaluronidase and reduces the permeability of the vascular wall.

Interacts with specific receptors in the cytoplasm of the cell, stimulates the synthesis of mRNA, inducing the formation of proteins, including lipocortin, mediating cellular effects. Lipocortin inhibits phospholipase A2, blocks the release of arachidonic acid and the biosynthesis of endoperoxides, prostaglandins, leukotrienes (promoting the development of inflammation, allergies and other pathological processes).

Salicylic acid, due to its keratolytic action, cleanses affected areas of scales, promotes the penetration of betamethasone into the skin, maintains the acidic environment of the skin, preventing the development of bacterial and fungal infections.

Special instructions

The drug is intended for external use only.

Avoid contact with eyes and mucous membranes, as well as use of the drug in the anogenital area.

It is not recommended to use the drug under an occlusive dressing, except when necessary.

If fungal or bacterial microflora develops on the skin, additional use of an antibacterial or antifungal agent is necessary.

The drug Belosalik® lotion in the form of a solution for external use is especially convenient for use on the scalp. The solution is easily distributed over the surface of the skin, does not stick or dry out hair, does not leave visible marks, and has a cooling effect on the skin.

Impact on the ability to drive vehicles and operate machinery

There is no data on the adverse effects of the drug on the ability to drive vehicles and machines.

Active ingredient

Betamethasone, Salicylic acid

Composition

1 g of solution contains:

Active substances:

betamethasone dipropionate – 640 mcg, which corresponds to the content of betamethasone – 500 mcg;

salicylic acid – 20 mg.

Excipients:

disodium edetate – 0.3 mg,

hypromellose 4000 cps – 5 mg,

sodium hydroxide – 5 mg,

isopropanol – 392 mg,

water – 577.06 mg.

Pregnancy

The use of the drug in pregnant women is permitted in cases where the expected benefit to the mother outweighs the risk to the fetus. In such cases, the use of the drug should be short-term and limited to small areas of the skin.

During breastfeeding, the use of Belosalik® lotion is possible according to strict indications, but the drug should not be applied to the skin of the mammary gland before feeding.

Contraindications

Lupus.
Skin manifestations of syphilis.
Chicken pox.
Viral skin infections.
Skin post-vaccination reactions.
Open wounds.
Trophic ulcers.
Rosacea.
Acne vulgaris.
Children’s age up to 6 months.
Hypersensitivity to betamethasone, salicylic acid or any of the auxiliary components of the drug.

Side Effects

Side effects are usually reversible and mild in nature.

On the part of the skin: possible development of hypersensitivity reactions (itching, burning, hyperemia), acne-like changes, hypopigmentation, stretch marks, skin atrophy, hypertrichosis, secondary skin infections.

With long-term continuous uncontrolled use and when applied to large areas of skin: telangiectasia, systemic manifestations of side effects of corticosteroids or salicylates.

If a hypersensitivity reaction or adverse reactions develop, the drug should be discontinued and consult a doctor.

Interaction

No clinically significant interactions with other drugs were observed.

Simultaneous use of cosmetic and dermatological products for external use containing ethanol, or medical soap with a pronounced drying effect, can cause skin irritation.

Overdose

Symptoms: manifestation of systemic side effects.

Treatment: drug withdrawal and symptomatic therapy are recommended.

Storage conditions

Store out of the reach of children at a temperature not exceeding 25°C.

Shelf life

2 years.

Manufacturer

Belupo, medicines and cosmetics d.d., Croatia