Baclosan, tablets 10 mg 50 pcs

Baclosan is an antispastic, myorelaxant.

Pharmacodynamics

Decreasing excitability of the end sections of afferent sensory fibers and suppressing intermediate neurons, inhibits mono- and polysynaptic transmission of nerve impulses; reduces pretension of muscle spindles. It has no effect on neuromuscular transmission. In neurological diseases accompanied by spasticity of skeletal muscles, weakens painful spasms and clonic convulsions; increases joint movement, facilitates passive and active kinesotherapy (physical exercises, massage, manual therapy).

Pharmacokinetics

After oral administration Cmax in plasma is reached after 2-3 hours. Absorption is high. Protein binding is 30%. It penetrates through the placental barrier and is excreted with breast milk. It is metabolized in the liver. It is excreted by the kidneys (mainly unchanged).

Indications

Active ingredient

Composition

The active ingredient is baclofen 10 mg;

Auxiliary substances – lactose, potato starch, gelatin, talc, magnesium stearate, ethyl cellulose.

How to take, the dosage

Ingestion, with meals. If another dose is missed, do not take a double dose of the drug.

Adults: The initial dose is 5 mg (1/2 tablet of 10 mg) 3 times a day. The dose can be gradually increased in each 3 days until the therapeutic effect is achieved (usually up to 30 – 75 mg per day). 25 mg tablets should be used for patients who require higher doses of Baclofen (from 75 mg to 100 mg per day). In patients over 65 years old the dose of the drug should be increased with caution due to the increased risk of side effects. The maximum daily dose is 100 mg.

Children: The starting dose is 5 mg (1/2 tablet of 10 mg) 3 times daily. If necessary, the dose may be increased with caution every 3 days. Usually the following doses are recommended: from 1 to 2 years of age – 10 to 20 mg per day, from 2 to 6 years of age – 20 to 30 mg per day, from 6 to 10 years of age – 30 to 60 mg per day. In children over 10 years old the maximum dose is 1.5 to 2.0 mg/kg of body weight.

Interaction

It enhances the effect of drugs affecting the central nervous system, hypotensive drugs, ethanol. Tricyclic antidepressants increase the reduction of muscle tone; levodopa and cardidopa increase the risk of hallucinations, confusion, agitation.

Patients should tell their doctor about all medications taken.

Special Instructions

In patients with liver disease and diabetes mellitus, the activity of “hepatic” transaminases, alkaline phosphotase, blood glucose should be periodically monitored. During treatment it is necessary to refrain from potentially hazardous activities that require increased attention and rapid mental and motor reactions.

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Contraindications

Side effects

Nausea, vomiting, drowsiness, dizziness, increased fatigue, dry mouth, confusion, gait disturbance, urinary retention, constipation or diarrhea, decreased blood pressure, apathy; euphoria, depression, paresthesias, myalgia, muscle weakness, ataxia, tremor, nystagmus, accommodation paresis, hallucinations, dysuria, enuresis, seizures, decreased seizure threshold.

In prolonged use – impaired renal function.

Overdose

Symptoms: muscle hypotonia, respiratory depression, confusion, coma (after return of consciousness muscle hypotonia may persist for 72 hours).

Treatment: plenty of fluids, diuretics, with respiratory depression – artificial lung ventilation. There is no specific antidote.