Aspirin-C, 400 mg+240 mg 10 pcs

Pharmacological action -regulating redox processes, increasing the body’s resistance, analgesic, antipyretic, anti-inflammatory.

Pharmacodynamics

Acetylsalicylic acid has analgesic, antipyretic, anti-inflammatory effects associated with inhibition of COX-1 and -2 that regulate the synthesis ofPH; inhibits platelet aggregation.

Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, helps improve the body’s resistance.

Indications

– Symptomatic treatment

– Symptomatic treatment.Strong> Moderate or mild pain syndrome of various origins (headache, toothache, migraine, neuralgia, muscle pain, menstrual pain);

– febrile syndrome with colds and other infectious and inflammatory diseases.

Active ingredient

Composition

1 tablet contains:

How to take, the dosage

Interaction

Enhances toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole).including co-trimoxazole), triiodothyronine, reserpine; reduces the effects of uricosuric drugs (benzbromaron, sulfinpyrazone), hypotensive drugs and diuretics (spironolactone, furosemide).

Enhances plasma concentrations of digoxin, barbiturates and lithium preparations.

GCS, alcohol and alcohol-containing drugs increase the damaging effect on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding.

Antacids containing magnesium and/or aluminum hydroxide slow down and impair absorption of acetylsalicylic acid.

Ascorbic acid improves intestinal absorption of iron preparations.

Special Instructions

The drug is not prescribed as antipyretic in children under 15 years of age with acute respiratory diseases caused by viral infections, because of the risk of Reye syndrome.

Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.

Possible drug interactions.

Glucocorticosteroids, alcohol increase the damaging effects on the gastrointestinal mucosa. One dose of the drug contains 933 mg of sodium, which should be considered in patients on a salt-free diet.

In order to reduce the risk of increased bleeding, the drug should be discontinued 4 to 8 days before a planned surgical procedure.

Contraindications

Children (under 15 years); hypersensitivity to any components of the drug and other NSAIDs; gastrointestinal erosive and ulcerative lesions (in the acute phase), gastrointestinal bleeding; acute inflammatory bowel disease; complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis, and intolerance to acetylsalicylic acid or other NSAIDs, including a history; concomitant use of methotrexate at a dose of 15 mg or more per week; marked hepatic and renal dysfunction; marked cardiac dysfunction; hemorrhagic diathesis; hemophilia, thrombocytopenia; glucose-6-phosphate dehydrogenase deficiency; Vitamin K deficiency; cerebrovascular or other bleeding; simultaneous use of oral anticoagulants and acetylsalicylic acid at a dose greater than 3 g per day; pregnancy (I and III trimesters), breast-feeding.

With caution: with concomitant therapy with anticoagulants, gout, gastric and/or duodenal ulcer (in anamnesis), erosive gastritis, and susceptibility to gastrointestinal bleeding, liver function disorders, hypothrombinemia, hypovitaminosis K, anemia, conditions predisposing to fluid retention in the body (including.including heart dysfunction, arterial hypertension), thyrotoxicosis, susceptibility to calcium-oxalate nephrolithiasis. Bronchial asthma, nasal polyposis, pollinosis, drug allergies, hypermenorrhea.

Side effects

Overdose

Symptoms: Mild intoxication may cause nausea, vomiting, epigastric pain, and (especially in children and elderly patients) tinnitus, dizziness, headaches, decreased vision and hearing.

In significant overdose, incoherent thinking, confusion, drowsiness, collapse, tremor, shortness of breath, choking, dehydration, hyperthermia, coma, alkaline reaction of urine, metabolic acidosis, respiratory (gas) alkalosis, carbohydrate metabolism disorders appear.

Lethal dose of acetylsalicylic acid in adults is more than 10 g, in children more than 3 g.

Treatment: depending on the state of acid-base balance and electrolyte balance, an infusion of sodium hydrocarbonate, sodium citrate or sodium lactate solutions is performed.

Pregnancy use

It is contraindicated in the I and III trimesters and during breastfeeding.

In the second trimester of pregnancy can be prescribed sporadically and with caution.