Pharmacological action -regulating redox processes, increasing the body’s resistance, analgesic, antipyretic, anti-inflammatory.
Acetylsalicylic acid has analgesic, antipyretic, anti-inflammatory effects associated with inhibition of COX-1 and -2 that regulate the synthesis ofPH; inhibits platelet aggregation.
Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, helps improve the body’s resistance.
Headache, Arthritis, Neuralgia, Arthritis, Sore throat, SARS, Painful menstruation (algodysmenorrhea), Fever, MIGRAINE, Hangover, Joint pain (arthralgia), Myalgia (muscle pain), Rheumatoid arthritis, Toothache, Colds, Flu
– Symptomatic treatment
– Symptomatic treatment.Strong> Moderate or mild pain syndrome of various origins (headache, toothache, migraine, neuralgia, muscle pain, menstrual pain);
– febrile syndrome with colds and other infectious and inflammatory diseases.
Acetylsalicylic acid, Ascorbic acid
1 tablet contains:
- acetylsalicylic acid 400 mg,
- ascorbic acid 240 mg.
How to take, the dosage
In pain syndrome of mild to moderate intensity and fevers, a single dose is 1 -2 effervescent tablets, the maximum single dose is 2 effervescent tablets, the maximum daily dose should not exceed 6 tablets. The intervals between the doses should be at least 4 hours.
Duration of treatment (without physician consultation) should not exceed 3-5 days.
In order to reduce the risk of adverse reactions in the gastrointestinal tract the minimum effective dose of the drug should be used for the shortest course of treatment.
Enhances toxicity of methotrexate, the effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole).including co-trimoxazole), triiodothyronine, reserpine; reduces the effects of uricosuric drugs (benzbromaron, sulfinpyrazone), hypotensive drugs and diuretics (spironolactone, furosemide).
Enhances plasma concentrations of digoxin, barbiturates and lithium preparations.
GCS, alcohol and alcohol-containing drugs increase the damaging effect on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding.
Antacids containing magnesium and/or aluminum hydroxide slow down and impair absorption of acetylsalicylic acid.
Ascorbic acid improves intestinal absorption of iron preparations.
The drug is not prescribed as antipyretic in children under 15 years of age with acute respiratory diseases caused by viral infections, because of the risk of Reye syndrome.
Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.
Possible drug interactions.
Glucocorticosteroids, alcohol increase the damaging effects on the gastrointestinal mucosa. One dose of the drug contains 933 mg of sodium, which should be considered in patients on a salt-free diet.
In order to reduce the risk of increased bleeding, the drug should be discontinued 4 to 8 days before a planned surgical procedure.
Children (under 15 years); hypersensitivity to any components of the drug and other NSAIDs; gastrointestinal erosive and ulcerative lesions (in the acute phase), gastrointestinal bleeding; acute inflammatory bowel disease; complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis, and intolerance to acetylsalicylic acid or other NSAIDs, including a history; concomitant use of methotrexate at a dose of 15 mg or more per week; marked hepatic and renal dysfunction; marked cardiac dysfunction; hemorrhagic diathesis; hemophilia, thrombocytopenia; glucose-6-phosphate dehydrogenase deficiency; Vitamin K deficiency; cerebrovascular or other bleeding; simultaneous use of oral anticoagulants and acetylsalicylic acid at a dose greater than 3 g per day; pregnancy (I and III trimesters), breast-feeding.
With caution: with concomitant therapy with anticoagulants, gout, gastric and/or duodenal ulcer (in anamnesis), erosive gastritis, and susceptibility to gastrointestinal bleeding, liver function disorders, hypothrombinemia, hypovitaminosis K, anemia, conditions predisposing to fluid retention in the body (including.including heart dysfunction, arterial hypertension), thyrotoxicosis, susceptibility to calcium-oxalate nephrolithiasis. Bronchial asthma, nasal polyposis, pollinosis, drug allergies, hypermenorrhea.
Gastrointestinal tract disorders: often – decreased appetite; rarely – diarrhea; frequency unknown – dyspepsia, abdominal pain, nausea, vomiting, overt (black stool, bloody vomiting) or latent signs of gastrointestinal bleeding, which may lead to iron deficiency anemia, erosive and ulcerative lesions (including with perforation) of the gastrointestinal tract.
Nervous system disorders: infrequent – headache; frequency unknown – dizziness, tinnitus (usually a sign of overdose).
Blood and lymphatic system disorders: frequency unknown-hemorrhagic syndrome, thrombocytopenia. Bleeding may lead to acute or chronic anemia, iron deficiency anemia with corresponding laboratory and clinical manifestations (asthenia, pallor, hypoperfusion). In patients with glucose-6-phosphate dehydrogenase deficiency hemolysis and hemolytic anemia may be observed.
Recreational and urinary tract disorders: frequency is unknown – when used in high doses – hyperoxaluria and formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.
Immune system disorders: incidence is unknown – skin rash, rhinitis, anaphylactic reactions, bronchospasm, Quincke’s edema, formation of “aspirin triad” (bronchial asthma, polyposis rhinosinusitis and intolerance of acetylsalicylic acid and pyrazolone products).
Hepatic and biliary tract disorders: very rarely – Reye’s syndrome (acute fatty liver with advanced acute liver failure and encephalopathy); rarely – liver dysfunction (increased liver transaminases).
If such symptoms occur, it is recommended to stop taking the drug and immediately contact the attending physician.
Symptoms: Mild intoxication may cause nausea, vomiting, epigastric pain, and (especially in children and elderly patients) tinnitus, dizziness, headaches, decreased vision and hearing.
In significant overdose, incoherent thinking, confusion, drowsiness, collapse, tremor, shortness of breath, choking, dehydration, hyperthermia, coma, alkaline reaction of urine, metabolic acidosis, respiratory (gas) alkalosis, carbohydrate metabolism disorders appear.
Lethal dose of acetylsalicylic acid in adults is more than 10 g, in children more than 3 g.
Treatment: depending on the state of acid-base balance and electrolyte balance, an infusion of sodium hydrocarbonate, sodium citrate or sodium lactate solutions is performed.
It is contraindicated in the I and III trimesters and during breastfeeding.
In the second trimester of pregnancy can be prescribed sporadically and with caution.
|Conditions of storage|
The drug should be stored at room temperature.
Bayer Bitterfeld GmbH, Germany
Bayer Bitterfeld GmbH
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