Ascorbic acid twist, tablets 25 mg, 10 pcs.

Indications

Hypo- and avitaminosis C.

An increased need for ascorbic acid (period of intense growth, pregnancy, lactation, increased physical activity, period of recuperation).

How to take, the dosage

Ingestion. Doses are given in terms of ascorbic acid.

Adults for prophylactic purposes – 50-100 mg/day, children – 25 mg/day.

Adults with therapeutic purpose – 50-100 3-5 times a day, children – 50-100 mg 2-3 times a day.

In pregnancy and lactation – 300 mg/day for 15 days, then 100 mg/day.

Interaction

Ascorbic acid: increases the blood concentration of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinylestradiol (including those included in oral contraceptives).
Improves intestinal absorption of Fe (converts trivalent iron to divalent iron); may increase iron excretion in concomitant use with deferoxamine.

Decreases the effectiveness of heparin and indirect anticoagulants.

ASA, oral contraceptives, fresh juices and alkaline drinking reduce absorption and absorption.

Concomitant use with ASA increases urinary excretion of ascorbic acid and decreases excretion of ASA.
ASA reduces absorption of ascorbic acid by about 30%.

It increases the risk of crystalluria when treated with salicylates and short-acting sulfonamides, slows renal excretion of acids, increases excretion of drugs with an alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives.

Enhances total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
Preventive agents of the quinoline series, CaCl2, salicylates, GCS deplete ascorbic acid reserves with long-term use.
With concomitant use it reduces the chronotropic effect of isoprenaline.

In long-term use or use in high doses may disrupt disulfiram-ethanol interaction.
In high doses increases renal excretion of mexiletine.

Barbiturates and primidone increase ascorbic acid excretion with urine.
Reduces therapeutic effects of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants.

Special Instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones it is necessary to monitor renal function and BP.

Long-term use of high doses may suppress pancreatic insular function, so it should be regularly monitored during treatment.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.
Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the process.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of “liver” transaminases and LDH).

Contraindications

Hypersensitivity, children (under 3 years).
With caution. Diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency; for use in high doses – hemochromatosis, sideroblast anemia, thalassemia, hyperoxaluria, nephrourolithiasis.

Overdose

Symptoms: with prolonged use of large doses (more than 1 g) – headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, hyperacidic gastritis, ulceration of the mucosa of the gastrointestinal tract, suppression of pancreatic insular apparatus function (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when dosing more than 600 mg/day).

Decrease capillary permeability (possible deterioration of tissue trophism, increased BP, hypercoagulation, development of microangiopathies.