Ascorbic acid tablets 50 mg 200 pcs

Pharmacotherapeutic group

Vitamin.

Pharmacological properties

Ascorbic acid actively participates in many redox reactions and has a non-specific general stimulating effect on the body. It increases the body’s adaptive capacity and resistance to infection and promotes regeneration processes.

Indications

Prevention and treatment of hypo-and avitaminosis of vitamin C.

As an adjunctive agent: hemorrhagic diathesis, nasal, uterine, pulmonary bleeding; overdose of anticoagulants; gastrointestinal diseases accompanied by impaired absorption of vitamin C; sluggishly healing wounds.

Elevated physical and mental stress, pregnancy and lactation, convalescence period after a serious long-term illness.

Composition

Composition per tablet:

Active ingredients: 0.05 g ascorbic acid

Additional ingredients: sugar, starch treacle, sunflower oil, wax, talcum powder, essence of flavor, quinoline yellow dye E-104.

How to take, the dosage

The drug is taken orally after meals.

For prophylaxis: 0.05-0.1 g (1-2 drops) for adults a day, 0.05 g (1 drop) a day for children from 5 years of age.

Treatment: 0.05-0.1 g (1-2 drops) for adults 3 to 5 times a day, for children from 5 years 0.05-0.1 g (1-2 drops) 2-3 times a day.

During pregnancy and breast-feeding 0.3 g (6 tablets) a day for 10-15 days, further 0.1 g (2 tablets a day) a day.

Interaction

Enhances blood concentrations of benzylpenicillin and tetracyclines; at a dose of 1 g / day increases the bioavailability of ethinylestradiol. Improves intestinal absorption of iron preparations (converts trivalent iron to divalent iron); may increase iron excretion in concomitant use with deferoxamine. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinking reduce absorption and assimilation.

Concomitant use with ASA increases urinary excretion of ascorbic acid and decreases excretion of ASA. Asc reduces absorption of ascorbic acid by about 30%. Increases the risk of crystalluria during treatment with salicylates and short-acting sulfonamides, delays renal excretion of acids, increases excretion of drugs that are alkaline (including alkaloids), reduces the blood concentration of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

The drugs of the quinoline series (fluoroquinolones, etc.), calcium chloride, salicylates, glucocorticosteroids with long-term use deplete ascorbic acid reserves.

In concomitant use reduces the chronotropic effect of isoprenaline.

In long-term use or use in high doses may disrupt disulfiram-ethanol interaction. In high doses increases renal excretion of mexiletine. Barbiturates and primidone increase excretion of ascorbic acid in the urine. Reduces therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubal reabsorption of amphetamine and tricyclic antidepressants.

Special Instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, adrenal function and blood pressure should be monitored.

Long-term use of high doses may suppress pancreatic insular function, so it should be regularly monitored during treatment.

In patients with elevated iron content in the body ascorbic acid should be used in minimal doses.

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. As a reducing agent, ascorbic acid may distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).

Contraindications

Hypersensitivity to the ingredients of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus.

With caution:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblast anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, advanced malignancies, pregnancy.

Overdose

If more than 1 g per day is taken, heartburn, diarrhea, difficulty urinating or staining the urine red, hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.

If any side effects occur, discontinue the drug and consult a physician.

Pregnancy use

The minimum daily requirement of ascorbic acid during the second and third trimesters of pregnancy is about 60 mg. The minimum daily requirement during breastfeeding is 80 mg. A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent vitamin C deficiency in the infant (it is recommended that the nursing mother does not exceed the maximum daily requirement of ascorbic acid).