Antigrippin, honey-lemon 5 g 3 pcs.

Combination drug.

Paracetamol has analgesic and antipyretic effects; relieves headache and other types of pain, reduces fever.

Chlorphenamine is a blocker of histamine H1-receptors; it has anti-allergic effect; it relieves nasal breathing, sneezing, lacrimation, itching and red eyes.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, increases the body’s resistance.

Indications

Colds, Fever, Nasal congestion, Angina, Headache, Sore throat, Joint pain (arthralgia), Muscle pain (myalgia), Flu, Chills, Runny nose (rhinitis) Infectious and inflammatory diseases (SARS, influenza) accompanied by fever, chills, headache, joint and muscle pain, stuffy nose and pain in the throat and sinuses.

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Composition

Active ingredients:
paracetamol……………………………………………………………………….500 mg
chlorphenamine maleate………………………………………………………………10 mg
ascorbic acid……………………………………………………………..200 mg

Excipients:

Honey lemon: sodium hydrocarbonate, citric acid, sorbitol, povidone, sucrose, sodium cyclamate, aspartame, acesulfame potassium, lime flavoring (Lime fruit flavor additive), caramel flavoring, honey flavoring, sodium docusate.

Chamomile: sodium bicarbonate, citric acid, sorbitol, povidone, sucrose, sodium cyclamate, aspartame, acesulfame potassium, chamomile extract, sodium docusate.

How to take, the dosage

Ingestion. Adults and children over 15 years: 1 sachet 2-3 times a day. The contents of the sachet should be dissolved completely in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The maximum daily dose is 3 sachets. The interval between doses of the drug should be at least 4 hours.

In patients with hepatic or renal impairment and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of use without consulting a physician is not more than 5 days when prescribed as a pain reliever and 3 days as an antipyretic.

Interaction

Ascorbic acid:
– increases the blood concentration of benzylpenicillin and tetracyclines;
– improves intestinal absorption of iron preparations (converts trivalent iron to divalent iron); may increase iron excretion when used simultaneously with deferoxamine; – It can both increase and decrease the effect of anticoagulant drugs. – reduces therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubal reabsorption of amphetamine and tricyclic antidepressants;
– concomitant use of barbiturates increases ascorbic acid excretion with urine.

Chlorphenamine maleate:
Chlorphenamine maleate increases the effect of hypnotic drugs. Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) – increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids – increase the risk of glaucoma. Ethanol increases the sedative effect of chlorphenamine maleate.

Paracetamol:
When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) the production of hydroxylated active metabolites increases, which leads to possible severe intoxications in small overdoses.

Ethanol promotes the development of acute pancreatitis when taking paracetamol.
Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects.

The concomitant use of diflunisal and paracetamol increases the plasma concentration of the latter by 50%, increasing hepatotoxicity. Concomitant use of barbiturates reduces the effectiveness of paracetamol.
Paracetamol reduces the effectiveness of uricosuric drugs.

Special Instructions

The use of metoclopramide, domperidone or colestiramine should also be consulted with the physician.

Long-term use at doses significantly higher than recommended increases the likelihood of liver and renal dysfunction, and peripheral blood counts should be monitored.

Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of plasma glucose and uric acid, bilirubin, activity of “hepatic” transaminases, LDH).

To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages, and should not be taken by persons prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with elevated iron levels in the body, ascorbic acid should be used at the lowest possible dose.

One sachet of honey and lemon has 1.793 grams of sugar, which is equivalent to 0.15 IU.

One sachet of chamomile has 2.058 grams of sugar, which corresponds to 0.17 IU.

Contraindications

High sensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug. Erosive ulcerative lesions of the gastrointestinal tract (in the acute phase). Expressed renal and/or hepatic insufficiency. Alcoholism. Closed-angle glaucoma. Phenylketonuria. Hyperplasia of the prostate gland. Childhood age (up to 15 years old). Pregnancy and lactation period.

With caution – renal and/or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcohol hepatitis, old age.

Side effects

The drug is well tolerated in the recommended doses.
In rare cases the following may be observed:
CNS disorders: headache, fatigue;
Gastrointestinal disorders: nausea, pain in the epigastric region;
Endocrine disorders: hypoglycemia (up to coma);
Hematopoietic disorders: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rare – thrombocytopenia;
allergic reactions: skin rash, itching, urticaria, Quincke’s edema, anaphylactoid reactions (includinganaphylactic shock), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome);
other: hypervitaminosis C, metabolic disorders, fever, dry mouth, accommodation palsy, urinary retention, drowsiness.

All side effects of the drug should be reported to your doctor.