Andipal, tablets 20 pcs

Pharmacotherapeutic group: analgesic (analgesic non-narcotic spasmolytic barbiturate).

ATC code: M02BB52.

Pharmacological properties

Combination drug. The combination of the drug components leads to mutual enhancement of their pharmacological action. Metamizole sodium is a pyrazolone derivative with analgesic and antipyretic effect. Bendazole (dibazole) is a vasodilator; it has a vasodilator effect, stimulates spinal cord function.

It has a direct antispasmodic effect on smooth muscles of blood vessels and internal organs. Facilitates synaptic transmission in the spinal cord. Papaverine hydrochloride is an antispasmodic agent, has a hypotensive effect, reduces tone and relaxes smooth muscles of internal organs and blood vessels. Phenobarbital in small doses has a sedative effect and enhances the effect of other components.

Indications

Pain syndrome (mild to moderately pronounced) in spasms of smooth muscles of internal organs:

• renal colic, biliary colic, intestinal colic;
• biliary dyskinesia, postcholecystectomy syndrome;
• spasm of the ureters and bladder;
• algodysmenorrhea.

Spasm of cerebral vessels, migraine.

As an adjunctive medicine: pain syndrome after surgery and diagnostic procedures.

Active ingredient

Bendazol, Sodium Metamizole, Papaverine, Phenobarbital

Composition

Per tablet:

Active ingredients:

Sodium metamizole (analgin) – 250 mg,

phenobarbital – 20 mg,

bendazole (dibazole) – 20 mg,

papaverine hydrochloride – 20 mg.

Excipients:

potato starch – 46 mg,

talc – 7 mg,

stearic acid – 3 mg,

calcium stearate – 4 mg.

How to take, the dosage

Orally, adults and children over 8 years old take 1 tablet 2-3 times a day. Duration of use without physician’s consultation should not exceed 7 days.

Interaction

Combination with nitrates (nitroglycerin, nitrosorbide, sustac etc.), calcium channel blockers (nifedipine, corinfar etc.), beta-adrenoblockers (anapriline, metoprolol, thalinolol etc.), ganglioblockers (pentamine etc.), diuretics (furosemide, hypothiazide etc.).

Simultaneous use with other non-narcotic analgesics may lead to mutual enhancement of toxic effects. Concomitant use with adsorbents, astringents and coating agents reduces absorption of the drug in the gastrointestinal tract.

Special Instructions

In case of long-term (more than 7 days) use it is necessary to monitor the peripheral blood picture and functional status of the liver.

During the treatment the drug should be avoided for potentially hazardous activities that require high concentration and quick psychomotor reactions.

The drug should be used by children and adolescents under 18 years old only by prescription.

Contraindications

• Hypersensitivity (including. Hypersensitivity (including to pyrazolone derivatives);
• inhibition of medullary hematopoiesis;
• expressed hepatic and/or renal insufficiency;
• deficiency of glucose-6-phosphate dehydrogenase;
• children
• under 8 years of age, pregnancy, period of tachyarrhythmia, severe angina pectoris.Children under 8 years of age, pregnancy, lactation, tachyarrhythmias, severe angina pectoris, collapse, decompensated chronic heart failure;
• closed angle glaucoma;
• prostate hyperplasia;
• intestinal obstruction, megacolon.

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Side effects

Allergic reactions.

Central nervous system: drowsiness, decreased rate of psychomotor reactions.

Gastrointestinal tract: nausea, constipation.

Cardiovascular system: arterial hypotension.

In long-term use: leukopenia, agranulocytosis, liver and kidney function disorders.

Similarities

Andipal