Pharmacotherapeutic group: analgesic combination medicine (analgesic non-narcotic + antispasmodic + barbiturate).
ATX code: N02BB72
p>Combination drug, has vasodilatory, analgesic, antispasmodic and sedative effects.
Andipal, as an antispasmodic agent, is used for spasms of peripheral blood vessels and cerebral vessels.
Lowering total peripheral resistance, acting on the arterioles, the drug reduces blood pressure and improves collateral circulation.
The combination of myotropic antispasmodics (bendazole and papaverine) with sodium metamizole increases the analgesic effect of the latter in headache and migraine. The presence of phenobarbital in the drug contributes to the sedative effect and enhances the action of the other components.
Sodium metamizole:is well and quickly absorbed into the gastrointestinal tract. In the intestinal wall it is hydrolyzed to form the active metabolite, unchanged sodium metamizole is absent in blood (only after intravenous administration a small concentration is found in plasma). Binding of active metabolite with plasma proteins is 50-60%. It is metabolized in the liver and excreted by the kidneys. In therapeutic doses penetrates into breast milk.
Papaverine:absorption depends on the dosage form. The bioavailability on average is 54%. Binding with plasma proteins – 90%. Well distributed, penetrates through histohematic barriers. It is metabolized in liver. Half-life (T1/2) is 0.5-2 hours (may be prolonged up to 24 hours). It is excreted by the kidneys as metabolites. Completely eliminated from the blood by hemodialysis.
Phenobarbital:when ingested, phenobarbital is completely but relatively slowly absorbed. The maximum concentration in the blood is observed 1-2 h after ingestion. About 50% is bound to plasma proteins. The drug is evenly distributed in different organs and tissues; lower concentrations are found in brain tissues. The half-life in adults is 2-4 days. It is excreted from the body slowly, which creates conditions for cumulation. It is metabolized by liver microsomal enzymes. It is excreted by kidneys as inactive metabolites and 25-50% – unchanged.
Spastic pain, Pain after injuries and operations, Vascular spasms, Urinary stone disease, Hypertension (high blood pressure), Colic, cholecystitis, Migraine, Pain, Headache, Biliary dyskinesia
- Pain syndrome associated with spasm of peripheral arteries, smooth muscles of the gastrointestinal tract, brain vessels;
- arterial hypertension.
Bendazol, Sodium Metamizole, Papaverine, Phenobarbital
1 tablet contains:
- metamizole sodium – 250 mg,
- bendazole – 20 mg, <
- papaverine hydrochloride – 20 mg,
- phenobarbital – 20 mg.
How to take, the dosage
Andipal is taken orally.
Adults – 1-2 tablets 2-3 times a day. The course of treatment is not more than 3 days.
If treatment is ineffective, the drug should be replaced or combined with other drugs (to achieve a hypotensive effect).
Pharmacological: combination with nitrates (Nitroglycerin, Nitrosorbide, Sustac, etc.), BCCs (Nifedipine, Corinfar), amiodarone, beta-adrenoblockers (Anapriline, Metoprolol, Oxprenolol, Thalinolol, etc.), diuretics (Furosemide, Hypothiazide, etc.).), ganglioblocators (pentamine, etc.), diuretics (Furosemide, Hypothiazide, etc.), myotropic antispasmodics (dipyridamole, eufylline, etc.) increase the hypotensive effect of Andipal.
The combined use of adrenomimetics of direct (adrenaline, noradrenaline, etc.) and indirect (ephedrine) type of action, n- and m-, n-cholinomimetics (nicotine, acetylcholine, etc.), analeptics (camphor, Sulfocamfocaine, Cordiamine, bemegrid, lobeline, cytisin, etc.), tonic agents (ginseng root, eleuterococcus extract, rhodiola extract, etc.) and Andipal reduce the hypotensive effect of the latter.
Pharmacokinetic: combined use of activated charcoal, astringents and coating agents reduces absorption of the drug in the gastrointestinal tract.
Caution should be exercised when operating machinery.
The blood count should be monitored with long-term use.
- hypersensitivity (including. Hypersensitivity (including to pyrazolone derivatives);
- inhibition of medullary hematopoiesis;
- explicit hepatic and/or renal insufficiency;
- deficiency of glucose-6-phosphate dehydrogenase;
- children under 8 years of age;
- pregnancy, period of breastfeeding;
- Tachyarrhythmias, stable angina III-IV functional class, unstable angina pectoris, spontaneous angina pectoris, collapse, decompensated chronic heart failure;
- closed angle glaucoma;
- prostate hyperplasia;
- respiratory diseases accompanied by obstructive syndrome;
- bronchial asthma provoked by taking acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;
- Atrioventricular conduction disorder;
- comatose condition;
- oppressed respiration;
- older age;
- diseases accompanied by increased muscle tone, seizure syndrome, porphyria (including anamnesis), myasthenia;
- alcohol or drug addiction.
Arterial hypotension, peripheral blood disorders, liver failure.
Sometimes nausea, constipation, allergic reactions (up to anaphylactic shock) occur.
In prolonged use of the drug may have a depressant effect on the blood due to the presence of analgin (leukopenia, rarely – agranulocytosis, thrombocytopenia).
Phenobarbital, which is present in the drug, may have a sedative effect; sometimes ataxia and depression may occur (especially in elderly and weak patients).
Symptoms: in case of overdose there is pronounced drowsiness, dizziness, collaptoid state.
Treatment: first aid – gastric lavage, taking activated charcoal. Symptomatic therapy.
Andipal is not recommended for children, pregnant and lactating women.
|Conditions of storage|
In a dry, light-protected place at a temperature not exceeding 25 °C
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