Andipal, tablets 10 pcs

Pharmacotherapeutic group: analgesic (analgesic non-narcotic spasmolytic barbiturate).

ATC code: M02BB52.

Pharmacological properties

Combination drug. The combination of the drug components leads to mutual enhancement of their pharmacological action. Metamizole sodium is a pyrazolone derivative with analgesic and antipyretic effect. Bendazole (dibazole) is a vasodilator; it has a vasodilator effect, stimulates spinal cord function.

It has a direct antispasmodic effect on smooth muscles of blood vessels and internal organs. Facilitates synaptic transmission in the spinal cord. Papaverine hydrochloride is an antispasmodic agent, has a hypotensive effect, reduces tone and relaxes smooth muscles of internal organs and blood vessels. Phenobarbital in small doses has a sedative effect and enhances the effect of other components.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Andipal

Symptoms of overdose: overdose of the drug is caused by the properties of its constituents. In overdose there is pronounced drowsiness dizziness collaptoid state.

Treatment: first aid – gastric lavage administration of activated charcoal. Symptomatic therapy aimed at maintaining vital functions. Treatment of intoxication as well as prevention of serious complications requires intensive medical supervision and treatment.

Sodium metamizole

Symptoms of overdose: acute overdose is manifested by nausea vomiting abdominal pain impaired renal function/acute renal failure (for example as a manifestation of interstitial nephritis) and rarely CNS symptoms (coma seizures) and decreased blood pressure leading to tachycardia and shock. In high overdose, excretion of rubazonic acid may stain the urine red.

Treatment: no specific antidote is known. In recent overdose, primary detoxification (e.g., gastric lavage) or sorption therapy (e.g., activated charcoal) is used to limit drug intake. The main metabolite (4N-methylaminoantipyrine) is removed by hemodialysis hemoperfusion and plasmafiltration. Treatment of overdose as well as prevention of serious complications may require general and special intensive medical supervision and treatment.

Phenobarbital

Symptoms of overdose: nystagmus ataxia headache congestion blurred speech pronounced weakness decrease or loss of reflexes agitation increase or decrease in body temperature depression of respiration shortness of breath decrease of blood pressure constriction of pupils (replaced by paralytic dilation) oliguria tachy or bradycardia cyanosis confusion consciousness cessation of electrical activity of brain edema coma later – pneumonia arrhythmia heart failure; at 2-10 g – lethal; with chronic toxicity – irritability impaired ability to critically appraise sleep disturbance confusion.

Treatment: no specific antidote. Gastric lavage administration of activated charcoal detoxification therapy symptomatic treatment maintenance of vital body functions.

Bendazole

Symptoms of overdose: There are no known cases of overdose. The most likely adverse event may be a marked decrease in blood pressure.

Treatment: If there is a pronounced decrease in blood pressure, put the patient in the supine position with the lower extremities elevated and apply symptomatic therapy.

Papaverine hydrochloride

Symptoms of overdose: diplopia (double vision) weakness decrease in blood pressure.

Treatment: symptomatic (maintenance of blood pressure).

Pregnancy use

The drug is contraindicated in pregnancy and during breastfeeding.

Pregnancy

The data on the use of the combined drug Andipal during pregnancy are limited. Sodium metamizole as a component of the drug penetrates the placenta. According to the results of preclinical studies the teratogenic effect of sodium metamizole was not detected. In spite of the fact that sodium metamizole weakly inhibits the synthesis of prostaglandins one cannot exclude premature (intrauterine) closure of the arterial duct as well as perinatal complications caused by disorder of platelet aggregation in mother or newborn.

Breast-feeding

Sodium metabolites of methamisole penetrate into breast milk; therefore, no breast-feeding should be done when using Andipal and also within 48 hours after the last dose.