Analgin Reneval, tablets 500 mg 10 pcs

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Indications

Fever syndrome in infectious and inflammatory diseases, insect bites, post-transfusion complications.

Pain syndrome (mild to moderate intensity): including neuralgia, myalgia, biliary colic, renal colic, postoperative pain syndrome, headache, toothache, algodysmenorrhea.

Active ingredient

Sodium metamizole

Composition

The active substance:

Metamizole sodium – 0.5 g,

Excipients:

potato starch – 0.0334 g,

sucrose (sugar) – 0.0055 g,

Calcium stearate – 0,0028 g,

Stearic acid – 0,0028 g,

Talc – 0,0055 g.

How to take, the dosage

Ingestion.

The maximum single dose is 1 g, the daily dose is 3 g.

For children from 8 years to 14 years the recommended dose is 250 mg, for children from 15 years and adults – 250-500 mg, the frequency of use is 2-3 times a day.

The duration of use without consulting a doctor is not more than 5 days.

Interaction

Rentgen contrast agents, colloidal blood substitutes and penicillin should not be used during treatment with sodium metamizole. Concomitant use of cyclosporine decreases the concentration of the latter in blood.

Sodium metamizole displaces oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from binding to plasma proteins and increases their activity.

Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes decrease the effectiveness of sodium metamizole when used concomitantly.

Simultaneous use with other non-narcotic analgesics, tricyclic antidepressants, contraceptive hormonal drugs and allopurinol may lead to increased toxicity.

Sodium metamizole increases the effects of ethanol; concomitant use with chlorpromazine or phenothiazine may lead to marked hyperthermia.

Sedative and anxiolytic drugs (tranquilizers) increase the analgesic effects of sodium metamizole

Thiamazole and cytostatics increase the risk of leukopenia.

The effect is enhanced by codeine, H2-histamine receptor blockers and propranololol (slows inactivation).

Myelotoxic drugs increase manifestations of hematotoxicity of the drug.

Special Instructions

When treating patients receiving cytostatic drugs, administration of sodium metamizole should be carried out only under medical supervision.

Patients with atopic bronchial asthma and pollinosis have an increased risk of allergic reactions.

In patients taking sodium metamizole, agranulocytosis may develop, therefore, if unexplained fever, chills, sore throat, difficulty swallowing, stomatitis, and if vaginitis or proctitis occur, the drug should be stopped immediately.

The peripheral blood count should be monitored with long-term use.

The drug should not be used for acute abdominal pain (until the cause is known).

Contraindications

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Side effects

Urinary system disorders: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine.

Allergic reactions: urticaria (including conjunctivitis and mucous membranes of the nasopharynx), angioedema, erythema malignant exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospastic syndrome, anaphylactic shock.

Hematopoietic disorders: agranulocytosis, leukopenia, thrombocytopenia.

Others: decreased blood pressure.

Overdose

Symptoms: nausea, vomiting, epigastric pain, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, seizures, paralysis of respiratory muscles.

Treatment: gastric lavage, saline laxatives, activated charcoal; conducting forced diuresis, hemodialysis, in case of convulsive syndrome – intravenous diazepam and quick-acting barbiturates.

Pregnancy use

Contraindicated.

Similarities

Analgin Ultra, Baralgin M, Analgin Renewal