Analgin, tablets 500 mg 20 pcs

Inalgin non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents the conduction of pain extra- and proprioceptive impulses.

Panalgin has a weak anti-inflammatory effect, resulting in little effect on water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract.

It has antispasmodic effect on the smooth muscle of the urinary and biliary tracts. The action develops 20-40 minutes after oral administration.

Pharmacokinetics

It is well and quickly absorbed in the gastrointestinal tract, which provides rapid development of the clinical effect. When administered in therapeutic doses, it penetrates into the mother’s milk.

The maximum concentration in plasma is reached 1-1.5 hours after oral administration.

In the intestinal wall it is hydrolyzed with the formation of the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites.

The level of binding of the active metabolite to proteins is 50-60%.

The excretion of metabolites passes through the kidneys. In addition, metabolites are excreted with breast milk.

Indications

Headache, Neuritis, Fever, Arthritis, Pain, Colic, Colds, Radiculitis, Toothache, Muscle pain, Joint pain, Gallstone disease, Urticaria, Neuralgia, Menstrual pain, Anesthesia, Pain after injuries and operations

• Pain syndrome (mild to moderate): incl. Headache, migraine, toothache, neuralgia, myalgia, radicular syndrome, algodysmenorrhea; with renal, hepatic and biliary colic (in combination with antispasmodic agents),
for pain reduction after surgical and diagnostic interventions,
• high body temperature in “colds” and other infectious and inflammatory diseases. The appropriateness of the drug is decided in each case, depending on the severity, nature and tolerability of fever.
  

Active ingredient

Sodium metamizole

How to take, the dosage

Orally, after meals, adults and children over 14 years of age are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, the daily dose is 3000 mg.

Children 8-14 years of age are prescribed 250 mg (1/2 tablet) 2-3 times a day.

The duration of use without consulting a doctor is not more than 5 days.

Interaction

Because of the high likelihood of pharmaceutical incompatibility, it should not be mixed with other drugs in the same syringe.

The concomitant use of analgin with other non-narcotic analgesics may result in mutually reinforcing toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol impair hepatic metabolism of analgin and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of analgin.

The concomitant use of analgin with cyclosporine reduces the blood levels of the latter.

Sedatives and tranquilizers increase the analgesic effect of analgin.

Special Instructions

In patients suffering from bronchial asthma and pollinosis, hypersensitivity reactions may develop.

When prolonged use (more than 7 days) it is necessary to monitor the peripheral blood picture. During sodium metamizole use agranulocytosis may develop, therefore in case of unexplained fever, chills, sore throat, difficulty in swallowing, stomatitis, erosive oral ulcers, vaginitis or proctitis the drug should be immediately discontinued.

Do not use for acute abdominal pain (until the cause is known).

To reduce the risk of gastrointestinal adverse events, the lowest effective dose should be used for the shortest possible course.

When treating patients receiving cytostatic agents, administration of sodium metamizole should be under medical supervision only.

Contraindications

• High sensitivity to pyrazolone derivatives (propiphenazone, phenazone or phenylbutazone);
• bronchial asthma induced by taking acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs);
• bronchoobstruction, rhinitis, urticaria, triggered by taking acetylsalicylic acid or other NSAIDs (incl.ч.
• Hematopoiesis suppression (agranulocytosis, cytostatic or infectious neutropenia);
• explicit hepatic or renal impairment;
  hepatic porphyria;
• hereditary hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency;
• pregnancy (especially in the 1st trimester and in the last 6 weeks);
• lactation period;
• children under 8 years old.

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Side effects

The drug is usually well tolerated in therapeutic doses.

When using Analgin tablets, adverse reactions may occur in some patients:

• allergic reactions (skin rash, Quincke’s edema; rarely – anaphylactic shock);
• with prolonged use, leukopenia may occur, rarely agranulocytosis.

In case of susceptibility to bronchospasm, provocation of an attack is possible.

Possible impairment of renal function.

Overdose

In case of overdose, a physician should be consulted.

The following symptoms may occur: nausea, vomiting, stomach pain, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, seizures, respiratory muscle paralysis.

Treatment: symptomatic. There is no specific antidote for sodium metamizole. In the conditions of the medical institution – carrying out forced diuresis, hemodialysis, in the development of a convulsive syndrome – intravenous administration of diazepam and fast-acting barbiturates.

Pregnancy use

Contraindicated.

Similarities

Analgin Ultra, Baralgin M, Analgin, Analgin Renewal