Analgin-quinine, 200 mg+50 mg 20 pcs

Algin-quinine is a combined drug, refers to analgesic non-narcotic drugs.

Quinine is an alkaloid of cinquefoil bark, has antipyretic effect, reduces excitability of the heart muscle, increases myometrium contractility, causes contraction of the spleen capsule, has a slight depressant effect on the CNS.

Methamisole sodium is a derivative of pyrazolone and has analgesic, antipyretic and mild anti-inflammatory action, whose mechanism is associated with inhibition of prostaglandin synthesis.

Indications

Pain syndrome of various etiologies, including:
headache,
neuralgia,
arthralgia,
myalgia,
myositis,
algodismenorrhea,
postoperative pain,
renal and biliary colic (in combination with antispasmodics).

Feverish conditions in infectious and inflammatory diseases.

Pharmacological effect

Analgin-quinine is a combination drug that belongs to analgesic non-narcotic drugs.

Quinine is an alkaloid of the cinchona bark, has an antipyretic effect, reduces the excitability of the heart muscle, increases myometrial contractility, causes contraction of the spleen capsule, and has a slight inhibitory effect on the central nervous system.

Metamizole sodium is a pyrazolone derivative and has analgesic, antipyretic and minor anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Special instructions

Analgin-quinine should be prescribed with caution to patients with impaired liver and kidney function, visual and hearing impairment, angina pectoris and heart failure.
With long-term (more than a week) use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary. It is advisable to monitor the ECG.

Impact on the ability to drive vehicles and operate machinery
While taking the drug, you should not perform work that requires increased attention and speed of psychomotor reactions.

Active ingredient

Metamizole sodium, Quinine

Composition

Active substance:

metamizole sodium (as 100%) 200 mg,

quinine hydrochloride 50 mg.

Excipients:

microcrystalline cellulose (Avicel PH 101) (75.00 mg),

sodium carboxymethyl starch (Primogel) (26.00 mg),

Kolidon-25 (povidone) (3.00 mg),

talc (5.00 mg),

magnesium stearate (1.00 mg).

Shell composition:

talc (4.10 mg), titanium dioxide (1.3005 mg), eudrahyde L 12.5 P (methacrylic acid and methyl methacrylate copolymer) (1.6832 mg), macrogol 400 (1.100 mg), glycerol (0.280 mg), castor oil (0.036 mg), green pigment dye (quinoline yellow dye E 104 + blue patent V E 131) (0.0001 mg).

Pregnancy

Contraindicated during pregnancy and lactation.

Contraindications

Hypersensitivity to the components of the drug Analgin-quinine.

Side Effects

skin rash and itching
pain and heaviness in the abdomen.

Interaction

Quinine may potentiate the action of drugs that block neuromuscular transmission.

Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

Chloramphenicol enhances the myelotoxic effect of metamizole sodium.

Concomitant use of the drug Analgin-Quinine with other analgesics and antipyretics may lead to increased toxic effects.

With simultaneous use of quinine with aminoglycoside antibiotics, a mutual increase in ototoxic effect may occur.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood.

Overdose

Symptoms: nausea, vomiting (including bloody), melena, epigastric pain, agranulocytosis, aplastic anemia, hemorrhagic diathesis, dizziness, tinnitus, clonic and tonic convulsions, cardiotoxic effect, skin rash (bullous, petechial, measles or typhoid), possible anaphylactic shock, coma.

Treatment: gastric lavage, prescription of laxatives and gastroprotective drugs, forced diuresis, restoration of breathing, anti-shock measures, restoration of blood volume; if necessary, symptomatic therapy; if seizures develop, IV barbiturates and diazepam. There is no specific antidote.

Storage conditions

The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life

5 years.

Manufacturer

Sopharma JSC, Bulgaria