Analgin-quinine, 200 mg+50 mg 20 pcs

Algin-quinine is a combined drug, refers to analgesic non-narcotic drugs.

Quinine is an alkaloid of cinquefoil bark, has antipyretic effect, reduces excitability of the heart muscle, increases myometrium contractility, causes contraction of the spleen capsule, has a slight depressant effect on the CNS.

Methamisole sodium is a derivative of pyrazolone and has analgesic, antipyretic and mild anti-inflammatory action, whose mechanism is associated with inhibition of prostaglandin synthesis.

Indications

Gallstone disease, Arthritis, Osteoarthritis, Migraine, Colds, Muscle pain, Toothache, Gout, Fever, Joint pain, trigeminal neuralgia, Arthritis, Back pain, Colic, MyositisA pain syndrome of various etiologies, including:

• headache,
• neuralgia,
• arthralgia,
• myalgia,
• myositis,
• postoperative pain,
• renal and biliary colic (in combination with antispasmodics).

Fever conditions in infectious and inflammatory diseases.

Active ingredient

Sodium metamizole, Quinine

Composition

Active ingredient:

Sodium metamizole (as 100%) 200 mg,

Quinine hydrochloride 50 mg.

Auxiliary substances:

Microcrystalline cellulose (Avicel PH 101) (75.00 mg),

sodium carboxymethyl starch (primogel) (26.00 mg),

colidone-25 (povidone) (3.00 mg),

talc (5.00 mg),

magnesium stearate (1.00 mg).

Composition of the shell:

Talc (4.10 mg), titanium dioxide (1.3005 mg), eudragide L 12.5 P (methacrylic acid and methyl methacrylate copolymer) (1.6832 mg), macrogol 400 (1.100 mg), glycerol (0.280 mg), castor oil (0.036 mg), pigment dye green (quinoline yellow dye E 104 + blue patented V E 131) (0.0001 mg).

How to take, the dosage

To be taken orally 1 to 2 tablets 1 to 3 times a day.

The drug Analgin-quinine should be taken immediately after a meal.

Interaction

Quinine may potentiate the effect of drugs that block neuromuscular transmission.

Tricyclic antidepressants, oral contraceptives, allopurinol impair the metabolism of sodium metamizole in the liver and increase its toxicity.

Chloramphenicol increases the myelotoxic effects of sodium metamizole.

The concomitant use of Analgin-Hinin with other antipyretic analgesics may lead to increased toxic effects.

The concomitant use of quinine with aminoglycoside antibiotics may result in mutual enhancement of ototoxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effects of sodium metamizole.

Sedatives and tranquilizers increase the analgesic effect of sodium metamizole.

The concomitant use of sodium metamizole with cyclosporine reduces the blood level of the latter.

Special Instructions

Caution should be exercised when prescribing Analgin-quinine to patients with liver and kidney function disorders, with visual and hearing impairment, with angina pectoris and heart failure.
With prolonged (more than a week) use of the drug, peripheral blood count and liver function monitoring is necessary. It is desirable to monitor ECG.

Impact on driving and operating machinery
While taking the drug it is not recommended to perform work requiring high attention and quick psychomotor reactions.

Contraindications

High sensitivity to the components of Analgin-quinine.

Side effects

• cutaneous rash and itching
• pain and heaviness in the abdomen.

Overdose

Symptoms: nausea, vomiting (including bloody), melena, epigastric pain, agranulocytosis, aplastic anemia, hemorrhagic diathesis, dizziness, tinnitus, clonic and tonic convulsions, cardiotoxic effect, skin rash (bullosa, petechial, crust-like or typhoid), possible anaphylactic shock, coma.

The treatment: gastric lavage, administration of laxatives and gastroprotective drugs, performance of forced diuresis, respiratory recovery, antishock measures, restoration of the circulatory volume; if necessary – symptomatic therapy, if convulsions develop – intravenous barbiturates and diazepam. There is no specific antidote.

Pregnancy use

It is contraindicated during pregnancy and lactation.