Analgin, 500 mg/ml 2 ml 10 pcs

An analgesic non-narcotic medicine.

ATX code [N02BB02]

Pharmacological properties

Pharmacodynamics

It has analgesic, antipyretic and mild anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis. It is a derivative of pyrazolone.

Pharmacokinetics

In intravenous administration: onset of action – after 5-10 minutes, maximum effect – after 5-30 minutes, duration of action – up to 2 hours. It is metabolized in the liver, a small concentration of unchanged sodium metamizole is found in the plasma, it is excreted by the kidneys. In therapeutic doses penetrates into the mother’s milk.

Indications

Active ingredient

Composition

How to take, the dosage

Parenteral administration is indicated only if oral administration is not possible.

We recommend warming to body temperature before administration.

Adults and adolescents 15 years and older: as a single dose, 1-2 ml 50% (500 mg/ml) sodium metamizole (intramuscular or intravenously) is recommended, the maximum daily dose may be up to 4 ml 50% injectable solution (no more than 2 g), divided into 2-3 doses. The maximum single dose can be 1 g (2 ml of 50% solution injected).

Children: Sodium metamizole is contraindicated under 3 months of age or if the body weight is less than 5 kg.

In children, sodium metamizole is indicated in a dose of 50-100 mg per 10 kg of body weight (0.1-0.2 ml of 50% solution).

A single dose can be prescribed up to 2-3 times a day.

Injection only intramuscularly for children aged 3-12 months (child weight 5-9 kg).

Intravenous infusion should be carried out slowly (infusion rate of no more than 1ml (500 mg of sodium metamizole per minute)) in the supine position, while monitoring blood pressure, pulse and respiratory rate to minimize the risk of reduced blood pressure.

At the first sign of anaphylactic/anaphylactoid reactions, discontinue the drug.

Because there is concern that the drop in blood pressure of non-allergic genesis is dose-dependent, amounts of sodium metamizole solution greater than 2 ml (1 g) should be administered with extreme caution.

A critical drop in blood pressure and shock may occur if the drug is administered too rapidly.

Elderly patients should use lower doses due to possible decreased excretion of sodium metamizole metabolites.

Patients in severe condition and with impaired creatinine clearance need to use lower doses due to a decreased excretion rate of sodium metabolites of metamizole.

In patients with impaired hepatic or renal function the excretion rate of the drug is slower; therefore repeated use of the drug should be avoided; no experience of long-term use is available.

Dose adjustment is not required for short-term therapy.

Length of treatment

When used as an analgesic, the duration is 1-5 days. When used as an antipyretic 1-3 days.

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Similarities