Amigrenin, 50 mg 6 pcs
€19.57 €16.31
Antimigraine drug. Specific selective agonist of serotonin 5HT1B-1D-receptors (5-hydroxytryptamine-1-like), located mainly in the smooth muscle of the walls of blood vessels of the brain.
Stimulation of 5HT1-receptors leads to selective vasoconstriction in the carotid artery system and reduction of neurogenic inflammation processes without significant effect on cerebral blood flow.
In addition, sumatriptan has been experimentally shown to inhibit trigeminal nerve activity.
These effects are thought to help reduce the severity of pain in migraine.
The clinical effect is noted 30 min after oral administration of the drug.
Indications
– relief of acute migraine attacks with or without aura.
Pharmacological effect
Antimigraine drug. A specific selective agonist of serotonin 5HT1B-1D receptors (5-hydroxytryptamine-1-like), located predominantly in the smooth muscles of the walls of blood vessels in the brain.
Stimulation of 5HT1 receptors leads to selective vasoconstriction in the carotid artery system and a decrease in neurogenic inflammation, without significantly affecting cerebral blood flow.
In addition, it has been experimentally established that sumatriptan inhibits the activity of the trigeminal nerve.
It is believed that these effects help reduce the severity of migraine pain.
The clinical effect is observed 30 minutes after oral administration of the drug.
Special instructions
Sumatriptan should be prescribed with extreme caution for epilepsy (including any condition with a decreased seizure threshold), as well as for patients with controlled arterial hypertension.
When prescribing Amigrenin to patients with newly diagnosed migraine or migraine with atypical symptoms, other potentially dangerous neurological diseases should be excluded. It must be borne in mind that patients with migraine are at risk of developing cerebrovascular complications (including stroke or transient cerebrovascular accident).
The drug should not be prescribed to patients at risk of developing pathology from the cardiovascular system, without prior examination to exclude the disease. The first 2-3 doses of the drug should be carried out under the supervision of a doctor (as spasm of the coronary arteries is possible).
In patients with hypersensitivity to sulfonamides, when taking sumatriptan, allergic reactions may develop, which range from skin manifestations to anaphylactic shock.
If there is no effect on the first dose, the diagnosis should be clarified.
Clinical experience with the drug in patients over 65 years of age is limited (no significant differences in pharmacokinetics are observed compared to younger patients).
Impact on the ability to drive vehicles and operate machinery
During therapy with sumatriptan, drowsiness may develop. Therefore, during the period of use of the drug, patients should be especially careful when driving a car and engaging in other potentially hazardous activities that require a high speed of psychomotor reactions.
Active ingredient
Sumatriptan
Composition
1 tab. sumatriptan (as succinate) 0.05 g
Excipients:
MCC;
milk sugar;
potato starch;
sodium carboxymethyl starch;
magnesium stearate;
hydroxypropylcellulose or hydroxypropylmethylcellulose;
PVP;
polyethylene glycol 4000;
talc;
titanium dioxide
Contraindications
– hemiplegic, basilar and ophthalmoplegic forms of migraine;
— IHD (including angina pectoris);
– occlusive diseases of peripheral arteries;
– uncontrolled arterial hypertension;
— stroke or transient cerebrovascular accident (including history);
– severe liver dysfunction;
– simultaneous use of drugs containing ergotamine or its derivatives;
– simultaneous use of MAO inhibitors and a period of up to 14 days after their discontinuation;
– pregnancy;
– lactation period (breastfeeding);
— age of patients under 18 years and over 65 years;
– hypersensitivity to the drug.
Side Effects
From the cardiovascular system: hyperemia of the skin and mucous membranes, arterial hypotension, tachycardia, palpitations, angina pectoris, transient increase in blood pressure, transient ischemic ECG changes, bradycardia; in isolated cases – manifestations of Raynaud’s syndrome.
From the side of the central nervous system: dizziness, weakness, drowsiness, feeling of fatigue; visual impairment (diplopia, scotoma, decreased visual acuity).
From the digestive system: discomfort in the abdomen, dysphagia, nausea, vomiting; rarely – ischemic colitis, increased activity of liver enzymes.
Allergic reactions: rash, itching, erythema, urticaria, anaphylaxis.
Other: possible sensations of tingling, warmth, heaviness, pressure or compression in various parts of the body, myalgia.
Interaction
When taken simultaneously with ergotamine, prolonged vasospasm was observed. Amigrenin can be prescribed no earlier than 24 hours after taking medications containing ergotamine.
Interaction between sumatriptan and MAO inhibitors is possible; their simultaneous use is contraindicated.
There are isolated reports of the development of weakness, hyperreflexia and loss of coordination in patients after concomitant use of sumatriptan and selective serotonin reuptake inhibitors. Amigrenin and drugs of this group should not be prescribed simultaneously.
Amigrenin and lithium preparations should not be prescribed simultaneously
Overdose
Treatment: in case of overdose, the patient should be observed for 10 hours, providing symptomatic therapy as necessary.
Manufacturer
Veropharm LLC, Russia
Manufacturer | Veropharm AO, Russia |
---|---|
Medication form | pills |
Brand | Veropharm AO |
Other forms…
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