Alpha-tocopherol acetate (vitamin E), 300 mg/ml 50 ml

Vitamin E is a natural antioxidant.

Protects cell membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes – hemoglobin, myoglobin, cytochromes, catalase, peroxidase.

Inhibits oxidation of unsaturated fatty acids and selenium. Inhibits the synthesis of cholesterol.

Prevent hemolysis of red blood cells, increased permeability and fragility of capillaries, impaired function of testicular and seminal tubules and placenta and normalizes reproductive function, prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscle.

Indications

Hypovitaminosis E; complex therapy of conditions accompanied by increased need of the body for vitamin E:
in muscular dystrophies, dermatomycosis, amyotrophic lateral sclerosis, asthenic and neurasthenic syndromes, overwork, paresis, myasthenia, myopathies, menstrual disorders, threatened pregnancy termination, menopause, disorders of sexual glands in men and women;

for dermatoses, psoriasis;

for respiratory mucosal atrophy, periodontal disease;

for rheumatic diseases: fibrositis, tendopathies, joint and spine disorders;

for endocrine disorders: thyrotoxicosis, diabetes, especially ketoacidosis, diabetic polyneuropathy;

in malabsorption syndrome, chronic liver diseases;

in myocardiodystrophy, spasms of peripheral vessels.

In the state of recuperation after diseases that occurred with a febrile syndrome.

Composition

30% oily solution of tocopherol acetate.

How to take, the dosage

For oral administration the drug is prescribed in the following dosages:

In diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc.) 50-100 mg per day (50-100 drops of 5% solution, 25-30 drops of 10% solution or 7-15 drops of 30% solution) for 1-2 months. Repeated courses in 2-3 months.

In men with spermatogenesis and potency disorders 100-300 mg per day (100-300 drops of 5% solution, 50-150 drops of 10% solution or 15-46 drops of 30% solution) in combination with hormonal therapy for a month.

In case of threatened abortion it is 100-150 mg per day (100-150 drops of 5% solution, 50-75 drops of 10% solution or 15-23 drops of 30% solution).
In habitual abortion and impaired intrauterine development of the fetus it is 100-150 mg per day (100-150 drops of 5% solution, 50-75 drops of 10% solution or 15-23 drops of 30% solution) in the first 2-3 months of pregnancy daily or every other day.

In case of peripheral vascular diseases, myocardiodystrophy, atherosclerosis, 100 mg per day (100 drops of 5% solution, 50 drops of 10% solution or 15 drops of 30% solution) in combination with vitamin A. Course duration is 20-40 days, after 3-6 months the treatment can be repeated.

In case of skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) for 20-40 days.

1 drop of an eye dropper contains: α – Tocopherol acetate in 5% solution – 1 mg, in 10% solution – 2 mg; in 30% solution – 6.5 mg.

Interaction

Increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides.

Prescribing vitamin E in high doses may cause vitamin A deficiency in the body.

It increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).

The simultaneous use of vitamin E in a dose greater than 400 units/day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding.

Colestyramine, colestipol, mineral oils reduce absorption.

High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Special Instructions

It should be noted that newborns with low birth weight may have hypovitaminosis E due to low placental permeability (fetal blood contains only 20-30% of the vitamin E concentration in the mother’s blood).

A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E.

Contraindications

With caution: hypoprothrombinemia (against vitamin K deficiency – may increase with a dose of vitamin E over 400 IU), severe coronary atherosclerosis, myocardial infarction, increased risk of thromboembolism.

Overdose

Symptoms: when taken over a long period at doses of 400-800 IU/day (1 mg = 1.21 IU) – blurred vision, dizziness, headache, nausea, extreme fatigue, diarrhea, gastralgia, asthenia; when taken over 800 IU/day for a long period – increased risk of bleeding in patients with hypovitaminosis K, Thyroid hormone metabolism disorders, sexual dysfunction, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites.

Treatment: symptomatic, drug withdrawal, administration of glucocorticosteroid drugs.