Akriderm GC, 0.05%+0.1%+1% cream 30 g

Pharmgroup:

Glucocorticosteroid+antibiotic-aminoglycoside+antifungal agent.

Pharmic action:

Acriderm GC is a combination drug, has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) action.
Betamethasone dipropionate – a glucocorticosteroid, has anti-inflammatory, anti-allergic, anti-exudative, anti-edema and antipruritic effect. It inhibits leukocyte accumulation, release of lysosomal enzymes and proinflammatory mediators in the inflammation focus, inhibits phagocytosis, decreases vascular and tissue permeability and prevents inflammatory edema formation.

Clotrimazole has antifungal action by disrupting the synthesis of ergosterol, which is a part of the cell membrane of fungi. It is active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides.

It has bactericidal action against pathogens of primary and secondary bacterial skin infections. It is active against Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerugenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; Gram-positive bacteria: Streptococcus spp. (sensitive strains of beta- and alpha-hemolytic Streptococcus group A), Staphylococcus spp. (coagulase-positive, coagulase-negative and some strains producing penicillinase).

Indications

Treatment of dermatoses complicated by primary and/or secondary infection, pityriasis, limited and diffuse neurodermatitis, dermatomycosis (including groin, foot) caused by pathogens sensitive to the drug.

Active ingredient

Composition

Outdoor cream 1 g:

betamethasone dipropionate 640 mcg,

clotrimazole 10 mg,

gentamicin sulfate 1 mg.

Associates:

Vaseline,

propylene glycol,

ceto stearyl alcohol,

Trilon B,

sodium dihydrophosphate dihydrate (sodium phosphate displacement 2-water),

water purified.

How to take, the dosage

Acriderm® GC is applied in a thin layer to the affected area of the skin twice a day, morning and evening. Other frequency of application can be determined by the physician according to the severity of the disease. In mild cases, once a day is usually sufficient; more frequent use may be necessary.

The duration of treatment depends on the effectiveness and tolerability of the therapy and is 2-4 weeks. If there is no clinical improvement, the diagnosis needs to be clarified.

Interaction

Interaction of the drug with other medicines has not been revealed.

Special Instructions

If signs of skin sensitivity or irritation associated with the use of the drug are noted, treatment should be discontinued and the patient should be treated appropriately.

In prolonged treatment, when applying the drug to large areas of skin, when using occlusive dressings, and in children, systemic absorption of corticosteroids is possible.

Atrophic changes may occur on the facial skin more often than on other body surfaces after long-term treatment with topical glucocorticosteroids.

Acriderm® GC is not indicated for use in ophthalmology. Avoid contact with the eyes. With prolonged use, withdraw the product gradually.

Contraindications

– Hypersensitivity to any of the ingredients of the drug;

– tuberculosis of the skin;

– cutaneous manifestations of syphilis;

– chicken pox;

– herpes simplex;

Side effects

When using glucocorticosteroids topically there may be: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis.

Long-term use or use of occlusive dressings causes skin maceration, secondary infection, skin atrophy, sweating, and purpura.

When applied to large body surfaces, mainly in children, systemic side effects of glucocorticosteroids (hyperglycemia, glucosuria, reversible inhibition of adrenal function, manifestation of Cushing’s syndrome) and gentamicin (nephrotoxic and ototoxic effects) may occur. If any adverse reactions not described in the instructions, seek medical attention.

Overdose

Acute overdose is unlikely; however, chronic overdose accompanied by signs of hypercorticism is possible with excessive or prolonged use of the drug: hyperglycemia, glucosuria, reversible suppression of adrenal cortex function, manifestation of Cushing’s syndrome.

Treatment.

The appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Pregnancy use

The safety of topical use of glucocorticosteroids in pregnant women has not been established; prescription of drugs of this group during pregnancy is justified only if the potential benefit exceeds the possible risk. During pregnancy, drugs of this group should not be used in high doses or for a long time.

It has not been established whether topical use of glucocorticosteroids can cause them to appear in the mother’s milk, so the question of stopping breastfeeding should be addressed.

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