Akriderm GC, ointment 30 g

A combination drug for external use with anti-inflammatory, anti-allergic, antifungal and antibacterial action.

Gentamicin is a broad spectrum bactericidal antibiotic of aminoglycoside group, highly active against Gram-negative bacteria Proteus spp. (indole-positive and indole-negative strains), Escherichia coli, Klebsiella spp, Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant). Active against Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Neisseria meningitidis, Treponema pallidum, anaerobic microorganisms (Streptococcus spp. (except Strepnococcus pneumoniae), Providencia rettgeri) are resistant to gentamicin.

Betamethasone has anti-inflammatory, anti-allergic, anti-exudative effects.

Clotrimazole is an antifungal agent from the group of imidazole derivatives. It acts by disrupting the synthesis of ergosterol, which is a part of the cell membrane of fungi. It has a wide spectrum of action. It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeasts and molds (Candida albicans, Turolopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics

In external application of the drug in therapeutic doses, transdermal absorption of the active substances into the blood is very low. When applied to the skin the intensity of absorption of betamethasone depends on the condition of the epidermal barrier (inflammation and skin diseases increase absorption).

The use of occlusive dressings increases transdermal absorption of betamethasone and gentamicin, which may increase the risk of systemic side effects.

Indications

Simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (including simple chronic lichen), eczema, ringworm (dermatophytosis, candidiasis, lichen versicolor), especially when localized in the groin area and large folds of the skin.

Pharmacological effect

A combined drug for external use with anti-inflammatory, antiallergic, antifungal and antibacterial effects.

Gentamicin is a broad-spectrum bactericidal antibiotic from the group of aminoglycosides, highly active against gram-negative bacteria Proteus spp. (indole-positive and indole-negative strains), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant). Active against Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. The following are resistant to gentamicin: Neisseria meningitidis, Treponema pallidum, anaerobic microorganisms (Streptococcus spp. (except Strepnococcus pneumoniae), Providencia rettgeri).

Betamethasone has anti-inflammatory, antiallergic, antiexudative effects.

Clotrimazole is an antifungal agent from the group of imidazole derivatives. It has an effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide spectrum of action. Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida albicans, Turolopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics

When the drug is used externally in therapeutic doses, transdermal absorption of the active substances into the blood is very insignificant. When applied to the skin, the intensity of absorption of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption).

The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.

Special instructions

Contact with eyes should be avoided.

If resistant bacterial or fungal microflora appears, the drug should be discontinued and appropriate therapy should be prescribed.

Due to the fact that in children the area of ​​skin in relation to body weight is larger than in adults, and the epidermis is underdeveloped, when the drug is used externally, it is possible to absorb a proportionately larger amount of active substances and, therefore, there is a greater risk of developing systemic side effects. The drug should be used in children for the shortest possible time and in compliance with all precautions.

Active ingredient

Betamethasone, Gentamicin, Clotrimazole

Composition

Active ingredients:

betamethasone dipropionate in terms of 100% substance – 0.064 g,

clotrimazole in terms of 100% substance – 1 g,

gentamicin sulfate in terms of genamicin – 0.1 g;

Excipients:

propyl parahydroxybenzoate (nipazole),

liquid paraffin (vaseline oil),

isopropyl myristate,

petrolatum.

Pregnancy

During pregnancy (especially in the first trimester), topical use of ointment in pregnant women is allowed only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In such cases, the use of the drug should be short-term and limited to small areas of the skin.

It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing Akriderm GK ointment during lactation, it is recommended to stop breastfeeding.

Contraindications

– skin tuberculosis;

– skin manifestations of syphilis;

– chicken pox;

– herpes simplex;

– skin post-vaccination reactions;

– open wounds;

– children under 2 years of age;

– hypersensitivity to the components of the drug.

With caution: the drug should be used during pregnancy, especially in the first trimester, in children aged 2 to 18 years.

Side Effects

Itching, burning, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypopigmentation, allergic reactions. When using occlusive dressings – maceration, infection, skin atrophy, stretch marks, prickly heat. With prolonged treatment or application to a large surface – the development of systemic side effects: weight gain, osteoporosis, increased blood pressure, edema, ulceration of the mucous membrane of the gastrointestinal tract, exacerbation of hidden foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

Interaction

The interaction of Akriderm GK with other drugs has not been established.

Overdose

Symptoms: phenomena of hypercortisolism.

Treatment: gradual withdrawal of the drug. Symptomatic therapy. If necessary, correct electrolyte disturbances.

Storage conditions

At temperatures from 15 to 25 °C. Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

Akrikhin JSC, Russia